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In the second decade, attention was focused on the degree of variability of this enzyme and the distinction of the various biochemical variants from one another. In the last decade, it has been possible to understand the mutations that effect this enzyme at the DNA level. Some 40 different mutations have now been characterized. Analysis of these mutations indicates that, while diversity sometimes exists within a mutation considered biochemical homogeneous, more often variants thought to be distinct prove to be identical. The study of G6PD mutations is beginning to provide insight into structurefunction relationships. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830420111","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:51:28Z","timestamp":1172062288000},"page":"53-58","source":"Crossref","is-referenced-by-count":68,"title":["Study of glucose\u20106\u2010phosphate dehydrogenase: History and molecular biology"],"prefix":"10.1002","volume":"42","author":[{"given":"Ernest","family":"Beutler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood.V14.2.103.103","article-title":"The hemolytic effect of primaquine and related compounds. 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