{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T23:49:41Z","timestamp":1725839381772},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4939,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010three patients reviewed from the literature and five cases of agranulocytosis during antibiotic therapy studied by the author are presented. Time required to develop agranulocytosis with antibiotics was &lt;19 days in comparison to &gt;40 days required with nonantibiotic drugs. In all, agranulocytosis occurred concomitantly with drug treatment and became normal as treatment was discontinued. Retrospective rechallenge studies suggest that agranulocytosis may be dose related. In all cases PMNs were almost completely deleted and marrows were devoid of granulocyte precursors. In contrast, leukopenia secondary to overwhelming sepsis displayed persisting granulocytes in peripheral blood and marrow. While leukagglutinins were not found in nine cited cases, four serums were toxic to test PMNs as measured by suppression of postphagocytosis respiratory burst. Clindamycin directly suppressed development of CFU\u2010G in one sensitive patient but not in 16 normal controls. The hazard of antibiotics in suppressing granulocytopoiesis is emphasized by these observations. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830420126","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:51:28Z","timestamp":1172062288000},"page":"132-137","source":"Crossref","is-referenced-by-count":10,"title":["Agranulocytosis during antibiotic therapy: Drug sensitivity or sepsis?"],"prefix":"10.1002","volume":"42","author":[{"given":"Anthony V.","family":"Pisciotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"77","article-title":"The effect of agranulocytotoxic drugs upon the influx of S35\u20101\u2010cystine and 1\u2010methionine in human leukocytes","volume":"32","author":"Pisciotta AV","year":"1959","journal-title":"Proc Cent Soc Cell Clin Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1958.02990160014004"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195807242590402"},{"key":"e_1_2_1_5_2","unstructured":"Adverse Reactions Registry on Tabulation of Reports. Panel on Hematology Council on Drugs Chicago: AMA July 1964; May 1965; June 1967."},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"BestWR: Chloramphenicol\u2010associated blood dyscrasias.JAMA201\u2013181 1967.","DOI":"10.1001\/jama.1967.03130030051012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197811000-00012"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.232.11.1150"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.232.11.1152"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.139.7.827"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5857.26"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5611.184"},{"key":"e_1_2_1_13_2","article-title":"A case of agranulocytosis occurring during the course of penicillin therapy","volume":"732","author":"Spain DM","year":"1946","journal-title":"Ann Intern Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212233072611"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197705000-00018"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197710000-00027"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80800-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197708000-00039"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90036-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-1-91"},{"key":"e_1_2_1_21_2","first-page":"301","article-title":"Bone marrow depression due to methicillin, a semisynthetic penicillin","volume":"5","author":"Levitt BH","year":"1964","journal-title":"J Pharm Ther"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196202012660507"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.232.11.1154"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90407-9"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-46-4-778"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-5-671"},{"key":"e_1_2_1_27_2","article-title":"Neutropenic reaction to cephalothin therapy","volume":"272","author":"Davis A","year":"1963","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.224.10.1427"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.2.174"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.194.6.668"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/ajcp\/69.5.559","article-title":"Agranulocytosis during therapy with orally administered cloxacillin","volume":"69","author":"Westerman EL","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_32_2","volume-title":"Clinical Hematology","author":"Wintrobe MM","year":"1981"},{"key":"e_1_2_1_33_2","first-page":"217","article-title":"Evidence for anti\u2010leukocyte antibodies as a mechanism for drug\u2010induced agranulocytosis","volume":"84","author":"McIntyre PA","year":"1971","journal-title":"Trans Assoc Am Phys"},{"key":"e_1_2_1_34_2","first-page":"207","volume-title":"Granulocyte serology: A clinical and laboratory guide","author":"McCullough J","year":"1988"},{"key":"e_1_2_1_35_2","first-page":"249","volume-title":"Hematopoietic Cellular Proliferation","author":"Robinson WA","year":"1970"},{"key":"e_1_2_1_36_2","first-page":"424","article-title":"Granulocytopenia caused by anticephalothin antibodies","volume":"19","author":"Levin AS","year":"1971","journal-title":"Clin Res"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91991-2"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02093.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01725189"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90915-7"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb07672.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830420126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830420126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T07:16:30Z","timestamp":1698218190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830420126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/ajh.2830420126"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830420126","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}