{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:34:49Z","timestamp":1791308089276,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the effects of human immunodeficiency virus type 1 (HIV\u20101) infection on the loss of factor VIII alloantibodies, we identified 77 patients with a history of inhibitors from among a large cohort of HIV\u20101\u2010infected participants enrolled in a natural history study of HIV\u20101 infection in hemophilia. Fifty\u2010six patients were high responders with inhibitors titers greater than 5 Bethesda Units (BU) measured on at least one occasion. From May 1985 to December 1989, 13 of the high\u2010responder patients were rechallenged with factor VIII concentrates after several years of treatment with other plasma products. All exhibited excellent hemostasis upon reinstitution of factor VIII. Seven of the 13 patients (11.3\u201346.3 years of age) were in the advanced stages of HIV\u20101 infection at the time of rechallenge. Inhibitor titers measured subsequent to the reinstitution of factor VIII were consistently less than 1 BU in five of these seven patients. The remaining six patients (6.1\u201357.5 years of age) had mild to moderate CD4+ lymphocyte depletion (absolute CD4+ cells: 262\u2013935\/ mm<jats:sup>3<\/jats:sup>) at the time of factor VIII rechallenge. Follow\u2010up inhibitor titers were negative 7\u201342 months after consistent factor VIII use in these six patients. The lack of anamnestic response to factor VIII in all 13 patients who were rechallenged indicates that HIV\u20101\u2010infected patients who have a history of high\u2010responder inhibitors frequently benefit from the reintroduction of factor VIII use for the control of bleeding, regardless of their stage of HIV\u20101 disease. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830420408","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:18:36Z","timestamp":1172063916000},"page":"375-379","source":"Crossref","is-referenced-by-count":107,"title":["Loss of high\u2010responder inhibitors in patients with severe hemophilia A and human immunodeficiency virus type 1 infection: A report from the multi\u2010center hemophilia cohort study"],"prefix":"10.1002","volume":"42","author":[{"given":"G. L.","family":"Bray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. L.","family":"Kroner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. W.","family":"Aledort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W.","family":"Hilgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Eyster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Goedert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood.V71.2.344.344","article-title":"The natural history of factor VIII:C inhibitors in patients with hemophilia A: A national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors","volume":"71","author":"McMillan CW","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb06370.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90874-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030803"},{"key":"e_1_2_1_6_2","first-page":"277","volume-title":"Factor VIII Inhibitors","author":"Lusher JM","year":"1984"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.1.31.31"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90259-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.1988.03720010043038","article-title":"Induction of immune tolerance to factor VIII in hemophiliacs with inhibitors","volume":"259","author":"Ewing NP","year":"1988","journal-title":"JAMA"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804143181503"},{"key":"e_1_2_1_11_2","first-page":"57","volume-title":"Progress in Hemostasis and Thrombosis","author":"Kasper CK","year":"1989"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.3.414"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29589284147.x"},{"issue":"1","key":"e_1_2_1_14_2","first-page":"343","article-title":"An effect of HIV infection on factor VIII (F.VIII) antibodies in hemophiliacs","volume":"70","author":"Hoots K","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910263211701"},{"key":"e_1_2_1_16_2","first-page":"19","volume-title":"Factor VIII Inhibitors","author":"Gill FM","year":"1984"},{"key":"e_1_2_1_17_2","first-page":"869","article-title":"A more uniform measurement of factor VIII inhibitors","volume":"34","author":"Kasper CK","year":"1975","journal-title":"Thromb Diath Haemorrh"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03340350037024"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308253090803"},{"key":"e_1_2_1_20_2","first-page":"24","article-title":"Pediatric acquired immunodeficiency syndrome: Demonstration of B lymphocyte defects in vitro","volume":"4","author":"Pahwa S","year":"1986","journal-title":"Diagn Immunol"},{"key":"e_1_2_1_21_2","first-page":"545","article-title":"Antibody responses to immunization of patients with hemophilia with and without evidence of human immunodeficiency virus (human T\u2010lymphotropic virus type III) infection","volume":"109","author":"Ragni MV","year":"1987","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_22_2","unstructured":"LusherJM ArkinS AbildgaardC et al.: Recombinant FVIII in previously untreated subjects with hemophilia A\u2010A 3.5 year observational study of safety efficacy and inhibitor development.N Engl J Med(in press)."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb03857.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199221000-00013"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830420408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830420408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:53:28Z","timestamp":1695880408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830420408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/ajh.2830420408"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830420408","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}