{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:45:30Z","timestamp":1764305130683},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4819,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombocytopenia after desmopressin (DDAVP) infusion is usually observed in patients with type IIB von Willebrand disease (vWD). No other subtypes of vWD with thrombocytopenia after DDAVP have been reported so far. We describe here the occurrence of thrombocytopenia after DDAVP in a 39 year old male and his son with phenotypic characteristics of type I vWD, 'platelet discordant subtype.' After DDAVP, the abnormal ristocetin cofactor\/von Willebrand factor antigen ratio in plasma was not corrected and the bleeding time remained markedly prolonged. Platelet count dropped 30 min after DDAVP (from 279 to 96 \u00d7 10<jats:sup>3<\/jats:sup>\/\u03bcL in the propositus and from 298 to 116 \u00d7 10<jats:sup>3<\/jats:sup>\/\u03bcL in his affected son) and returned to normal at 60 min. Platelet clumping was evident on peripheral blood smears obtained after infusion. These cases indicate that after DDAVP thrombocytopenia can occur in vWD other than type IIB.<\/jats:p>","DOI":"10.1002\/ajh.2830430103","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:16:38Z","timestamp":1172063798000},"page":"5-9","source":"Crossref","is-referenced-by-count":16,"title":["Desmopressin\u2010induced thrombocytopenia in type i platelet discordant von willebrand disease"],"prefix":"10.1002","volume":"43","author":[{"given":"Giancarlo","family":"Castaman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Rodeghiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Lattuada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Mannuccio","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(91)90032-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1992.tb01198.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091402"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood.V66.4.796.796","article-title":"Heterogeneity of type I von Willebrand's disease: Evidence for a subgroup with an abnormal von Willebrand factor","volume":"66","author":"Mannucci PM","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-0038-1647316","article-title":"von Willebrand factor antigen is less sensitive than ristocetin cofactor for the diagnosis of type I von Willebrand disease\u2014Results based on an epidemiological investigation","volume":"64","author":"Rodeghiero F","year":"1990","journal-title":"Thromb Haemostas"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1182\/blood.V71.1.65.65","article-title":"von Willebrand's disease \u201cVicenza\u201d with larger\u2010than\u2010normal (supranormal) von Willebrand factor multimers","volume":"71","author":"Mannucci PM","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1988.tb00815.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(90)90129-Z"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005083021902"},{"key":"e_1_2_1_12_2","first-page":"318","article-title":"Variant von Willebrand disease. 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