{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:54Z","timestamp":1760188854065},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4788,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 45\u2010year\u2010old female with a long history of HLA\u2010B27\u2010positive ankylosing spondylitis and ulcerative colitis developed cyclic neutropenia. She was hospitalized for high fever during each of three consecutive episodes of absolute neutropenia. On the third hospitalization, granulocyte\u2010colony\u2010stimulating factor (G\u2010CSF), 5 \u03bcg\/kg\/day, was given by subcutaneous injection and resulted in an increase of absolute neutrophil count from 0 to 2.2 \u00d7 10<jats:sup>9<\/jats:sup>\/liter and an associated decrease of platelet count and hemoglobin as well as severe bone and joint pain predominantly in the middle and lower back and purulent diarrhea. The back pain necessitated discontinuation of the drug. Oral cyclosporine therapy was begun, and although the neutrophil count continued to oscillate, both the peaks and the nadirs were higher than previously, and symptoms of neutropenia subsided. We conclude that cyclosporine can be an effective treatment for cyclic neutropenia associated with autoimmunity since G\u2010CSF may cause exacerbations of autoimmune disorders.<\/jats:p>","DOI":"10.1002\/ajh.2830430213","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:16:06Z","timestamp":1172063766000},"page":"139-143","source":"Crossref","is-referenced-by-count":9,"title":["Adult\u2010onset cyclic neutropenia responsive to cyclosporine therapy in a patient with ankylosing spondylitis"],"prefix":"10.1002","volume":"43","author":[{"given":"Jan","family":"Storek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Glaspy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne W.","family":"Grody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Susi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan D.","family":"Slater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(88)90023-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb04192.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb15770.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205986"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.6.2089"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198905183202003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197802092980602"},{"key":"e_1_2_1_9_2","first-page":"9","article-title":"Acquired cyclic neutropenia: Successful treatment with prednisone","volume":"22","author":"Rodgers GM","year":"1982","journal-title":"Am J Hematol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02631.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1990.tb00451.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1990.tb00428.x"},{"key":"e_1_2_1_13_2","first-page":"251","article-title":"Myeloid progenitor cell growth characteristics and effect of G\u2010CSF in a patient with congenital cyclic neutropenia","volume":"54","author":"Tsunogake S","year":"1991","journal-title":"Int J Hematol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02221322"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1182\/blood.V76.3.523.523","article-title":"A comparison of treatment of canine cyclic hematopoiesis with recombinant human GM\u2010CSF. 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