{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:08Z","timestamp":1760188868361},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4727,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the use of \u03b1<jats:sub>2b<\/jats:sub>\u2010interferon in 15 children with symptomatic, chronic idiopathic thrombocytopenic purpura, who did not respond to standard therapy. The platelet count increased in nine children during therapy. In six children the increase lasted less than 6 weeks. An increased platelet count was seen when a higher dose was used in two of four initial nonresponders. One responder who relapsed had an identical response when retreated with the same dose. No significant side effects were documented. Further studies are required to establish the optimal dose and administration schedule of \u03b1<jats:sub>2b<\/jats:sub>\u2010interferon for use in children with chronic idiopathic thrombocytopenic purpura.<\/jats:p>","DOI":"10.1002\/ajh.2830430403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:13:38Z","timestamp":1172063618000},"page":"246-250","source":"Crossref","is-referenced-by-count":10,"title":["\u03b1\u2010interferon therapy for severe chronic idiopathic thrombocytopenic purpura in children"],"prefix":"10.1002","volume":"43","author":[{"given":"Richard J.","family":"Cohn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Schwyzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Hesseling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Naidoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrieta","family":"Van Heerden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1343","volume-title":"Hematology of Infancy and Childhood","author":"Stuart MJ","year":"1987"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6612.1519"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6612.1519-a"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1182\/blood.V74.6.1894.1894","article-title":"Improvement of platelet counts in steroid\u2010unresponsive idiopathic immune thrombocytopenic purpura after short\u2010course therapy with recombinant alfa\u20102b interferon","volume":"74","author":"Proctor SJ","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_6_2","first-page":"1745","article-title":"Recombinant interferon alfa\u20102B in refractory idiopathic immune thrombocytopenia (Response to letter)","volume":"75","author":"Proctor SJ","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90005-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1200\/JCO.1985.3.5.654","article-title":"Phase II study of recombinant alpha\u20102 interferon in resistant multiple myeloma","volume":"3","author":"Constanzi JJ","year":"1985","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1182\/blood.V69.5.1280.1280","article-title":"Clinical investigation of human alpha interferon in chronic myelogenous leukaemia","volume":"69","author":"Talpaz M","year":"1987","journal-title":"Blood"},{"issue":"1","key":"e_1_2_1_10_2","first-page":"472","article-title":"Alpha interferon therapy for treatment of steroid resistant immune thrombocytopenia (ITP)","volume":"76","author":"Proctor SJ","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.8.701"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.4.316"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1182\/blood.V75.8.1744.1744","article-title":"Recombinant interferon alfa\u20102B in refractory idiopathic immune thrombocytopenia","volume":"75","author":"Hurtado R","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90701-6"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830430403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830430403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:36:43Z","timestamp":1698295003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830430403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1002\/ajh.2830430403"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830430403","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}