{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:10:02Z","timestamp":1698383402931},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4727,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In \u03b2P\u00b0\u2010thalassemia and sickle cell patients, a 4 bp deletion at \u2013222 to \u2013225 of the <jats:sup>A<\/jats:sup>\u03b3 globin promoter was associated with low expression of the <jats:sup>A<\/jats:sup>\u03b3<jats:sup>T<\/jats:sup> variant (threonine at codon 75 of <jats:sup>A<\/jats:sup>\u03b3), whereas <jats:sup>A<\/jats:sup>\u03b3<jats:sup>I<\/jats:sup> (isoleucine at 75) had the normal <jats:sup>A<\/jats:sup>\u03b3 promoter and higher expression. However, it has been reported that the \u03b2<jats:sup>A<\/jats:sup> chromosomes of sickle cell trait cases have the 4 bp deletion as a common polymorphism unlinked lo the <jats:sup>A<\/jats:sup>\u03b3<jats:sup>T<\/jats:sup> allele. We now present data demonstrating the association of the <jats:sup>A<\/jats:sup>\u03b3<jats:sup>T<\/jats:sup> allele with the 4 bp deletion in \u03b2<jats:sup>A<\/jats:sup> chromosomes of sickle cell traits.<\/jats:p>","DOI":"10.1002\/ajh.2830430418","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:13:38Z","timestamp":1172063618000},"page":"312-315","source":"Crossref","is-referenced-by-count":3,"title":["Direct demonstration that the <sup>A<\/sup>\u03b3<sup>T<\/sup> globin gene is linked to the 4 bp promoter deletion in the \u03b2<sup>A<\/sup> chromosome of sickle cell traits"],"prefix":"10.1002","volume":"43","author":[{"given":"John G.","family":"Gilman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olgica","family":"Josifovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soili","family":"Erlingsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283367"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb04235.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb04390.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221951"},{"key":"e_1_2_1_6_2","first-page":"9473","article-title":"A four\u2010base deletion 5\u2032 to the A\u03b3 globin gene is a common polymorphism","volume":"78","author":"Coleman MB","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_7_2","first-page":"170A","article-title":"\u03b2S and \u03b2A chromosomes with Eton haplotype show the four bp deletion in promoter of the A\u03b3T globin gene in association with tighter binding of a nuclear protein","volume":"40","author":"Gilman JG","year":"1992","journal-title":"Clin Res"},{"key":"e_1_2_1_8_2","first-page":"1175","article-title":"G\u03b3 and A\u03b3 globin genes are identical from \u2014398 of the promoter midway through IVSII in a Benin \u03b2S haplotype associated with elevated Hb F","volume":"48","author":"Mishima N","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_2","first-page":"3a","article-title":"The four base deletions 5\u2032 to the A\u03b3T allele is associated with not only the decreased production of A\u03b3T\u2010globin, but also the production of G\u03b3\u2010 globin from the G\u03b3 allele in cis","volume":"80","author":"Coleman MB","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_10_2","first-page":"320","article-title":"An A\u03b3 globin promoter (four base\u2010pair deletion) mutant shows linked polymorphic changes throughout the A\u03b3 gene","volume":"20","author":"Harvey MP","year":"1992","journal-title":"Exp Hematol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.16.6681"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830430418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830430418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:38:24Z","timestamp":1698295104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830430418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1002\/ajh.2830430418"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830430418","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}