{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T10:26:21Z","timestamp":1778408781311,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4696,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adoptively transferred immune cells in combination with chemotherapeutic agents form the basis for adoptive chemoimmunotherapy (ACIT) of neoplastic disease. Autolympho\u2010cytes (ALT\u2010cells) are ex vivo activated peripheral blood lymphocytes (PBL) from tumor\u2010bearing hosts (TBH) that consist primarily of tumor\u2010specific CD45RO<jats:sup>+<\/jats:sup> (memory) T\u2010cells. These ALT\u2010cells combined with cimetidine (CIM) as autolymphocyte therapy (ALT), have previously been demonstrated to be a safe and active form of outpatient adoptive immunotherapy (AIT) in human TBH with metastatic renal cell cancer (RCC). We have previously described an effective ACIT protocol using ALT and cyclophosphamide (CY) for patients with relapsed and refractory non\u2010RCC solid tumors. We now report a case of a patient with a metastatic gastric leiomyosarcoma to the liver, who developed a clinical picture consistent with a tumor\u2010lysis syndrome (TLS), following salvage therapy for his tumor with ACIT using ALT and CY. TLS is a well\u2010known complication resulting from the treatment of rapidly proliferating hematopoietic tumors such as Burkitt's lymphoma and acute lymphocytic leukemia. TLS has also been rarely described in chronic lymphocytic leukemia, as well as certain solid tumors such as breast cancer, small cell lung cancer, and medulloblastoma. However, there have been no previous reports of TLS occurring either secondary to immunotherapy or in sarcomas. The nature of these unusual findings is discussed. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830440109","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:13:10Z","timestamp":1172063590000},"page":"42-47","source":"Crossref","is-referenced-by-count":26,"title":["Adoptive chemoimmunotherapy using Ex vivo activated memory T\u2010cells and cyclophosphamide: Tumor lysis syndrome of a metastatic soft tissue sarcoma"],"prefix":"10.1002","volume":"44","author":[{"given":"Jay E.","family":"Gold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Malamud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Larosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Osband","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.3.952"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.5.1122"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.4049\/jimmunol.139.9.3166","article-title":"Adoptive chemoimmunotherapy of murine leukemia with helper T\u2010lymphocyte clones","volume":"139","author":"Bookman MA","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.231"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420627"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4049\/jimmunol.138.2.641","article-title":"Successful treatment of advanced murine renal cell cancer by bicompartmental adoptive chemoimmuno\u2010therapy","volume":"138","author":"Salup RR","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812223192527"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911201)68:11<2391::AID-CNCR2820681110>3.0.CO;2-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91064-H"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80084-Z"},{"key":"e_1_2_1_12_2","unstructured":"GoldJE OsbandME:Autolymphocyte therapy: I. 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In press."},{"key":"e_1_2_1_13_2","first-page":"740","article-title":"Autolymphocyte therapy (adoptive immunotherapy with ex vivo activated memory T\u2010cells) of human renal cell carcinoma: Potentiation by cis\u2010diamminedichloroplatinum(II)","volume":"12","author":"Gold JE","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_14_2","first-page":"506","article-title":"The immunologic mechanism of autolymphocyte therapy in the successful treatment of renal cell carcinoma (RCC) is the infusion of activated memory T\u2010cells","volume":"145","author":"Celis E","year":"1991","journal-title":"J Urol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199304000-00009"},{"key":"e_1_2_1_16_2","first-page":"1671","article-title":"Effect of low dose cyclophosphamide on the immune system of cancer patients: Depletion of CD4+2H4+ suppressor\u2010inducer T\u2010cells","volume":"48","author":"Berd D","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1509"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037698"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90286-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198105000-00005"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.239.23.2472"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840415)53:8<1783::AID-CNCR2820530829>3.0.CO;2-F"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851101)56:9<2295::AID-CNCR2820560926>3.0.CO;2-X"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.249.4.513"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870815)60:4<762::AID-CNCR2820600409>3.0.CO;2-P"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.147.2.375"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900715)66:2<246::AID-CNCR2820660209>3.0.CO;2-B"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197405000-00007"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<926::AID-CNCR2820360313>3.0.CO;2-G"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206969"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111863"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(89)90138-X"},{"key":"e_1_2_1_33_2","first-page":"139","article-title":"Radiosensitivity of T\u2010lympho\u2010cyte subpopulations","volume":"7","author":"Wasserman J","year":"1982","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_1_34_2","first-page":"3134","article-title":"Radiosensitive, thymic\u2010hormone sensitive peripheral blood suppressor cell activity in cancer patients","volume":"40","author":"Hersh EM","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310414"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290510"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410320071009"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199111000-00006"},{"key":"e_1_2_1_39_2","first-page":"83","article-title":"Smooth muscle tumors of the gastrointestinal tract","volume":"10","author":"Appelman H","year":"1986","journal-title":"Am J Surg Pathol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830440109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830440109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:19:00Z","timestamp":1698301140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830440109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/ajh.2830440109"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830440109","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}