{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:33Z","timestamp":1760244933391},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4696,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient presented with lymphoblastic lymphoma in lymph\u2010nodes and chronic myeloge\u2010nous leukemia (CML) in marrow and peripheral blood. All marrow and unstimulated peripheral blood cells contained the Philadelphia chromosome{t(9:22)}. Lymphoma cells were analyzed by flow cytometry and were identified as T cells (CD2+CD5+CD7+CD34+). All fresh lymphoma cells contained the t(9:22) translocation. Cultures of purified peripheral blood T and B cells and specifically stimulated NK cells revealed that 59% of the B cells, 10% of the NK cells, and none of the normal T cells contained the translocation. The lack of translocation in normal peripheral T cells is attributed to their long lifespan. No rearrangement of immunoglobulin or T cell receptor beta or gamma genes was found in either the leukemia or lymphoma cells. Analysis of the DNA from cryopreserved lymphoma biopsy showed clonal rearrangement within the common breakpoint cluster region of the bcr gene identical to the bcr rearrangement in DNA from leukemia blood cells. The data support the concept that T and B cells originate in the patient's totipotent stem cell from which the CML is also derived. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830440110","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:13:10Z","timestamp":1172063590000},"page":"48-52","source":"Crossref","is-referenced-by-count":13,"title":["Simultaneous demonstration of the Philadelphia chromosome in T, B, and myeloid cells"],"prefix":"10.1002","volume":"44","author":[{"suffix":"Jr.","given":"Archie A.","family":"Mackinney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Borcherding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fizzotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"6066","article-title":"Characterization of human uroepithelial cells immortalized in vitro by Simian virus 40","volume":"47","author":"Christian BJ","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_2","first-page":"2876","article-title":"Philadelphia chromosome\u2010positive acute lymphoblastic leukemia cell lines without classical breakpoint cluster rearrangement","volume":"48","author":"Naumovski L","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3422516"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8563"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/316464a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/312521a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1182\/blood.V19.2.236.236","article-title":"Determination of lymphocyte turnover by continuous infusion of H3\u2010thymidine","volume":"19","author":"Little JR","year":"1962","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.147.3659.745"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/214470a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1182\/blood.V26.6.798.798","article-title":"Unstable chromosome changes in tuberculin\u2010stimulated leukocyte cultures from irradiated patients. 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