{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:10:02Z","timestamp":1698383402976},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4696,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder arising from a single hematopoietic cell. Approximately 5% of reported cases of AMM have terminated in leukemic crisis; however, the precise characteristics of the leukemic cells have rarely been reported. We report a case of AMM that occurred in a 42\u2010year\u2010old man and was complicated by leukemic transformation. The leukemic cells wer morphologically lymphoblastoid cells with a negative reaction to peroxidase staining, and phenotypically characterized as CD7+, CD34+, HLA\u2010DR+, CD4\u2212, CD8\u2212, CD10\u2212, CD13\u2212, and CD33\u2212. Southern blot analysis revealed that T cell receptor\u2010\u03b2, \u03b3, and immunoglobulin heavy chain genes in leukemic cells were retained in germ\u2010line configuration. These observations suggest that leukemic cells in our case involved early hematopoietic stem cells rather than those strictly committed to myeloid or lymphoid precursors. To our knowledge, this is the first report of stem cell leukemia arising in a patient with AMM. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830440111","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:13:10Z","timestamp":1172063590000},"page":"53-57","source":"Crossref","is-referenced-by-count":5,"title":["Cd7, CD34\u2010positive stem cell leukemia arising in agnogenic myeloid metaplasia"],"prefix":"10.1002","volume":"44","author":[{"given":"Taizo","family":"Tasaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Murao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kitanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terukazu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Takahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Irino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V51.2.189.189","article-title":"Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary my\u2010elofibrosis","volume":"51","author":"Jacobson RJ","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02227.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/00325481.1969.11697057","article-title":"Myeloid metaplasia: A study of 98 cases","volume":"46","author":"Rosenthal DS","year":"1969","journal-title":"Postgrad Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archinte.1973.03650110057012","article-title":"Idiopathic myeloid metaplasia: Its evolution in the acute leukemia","volume":"132","author":"Silverstein MN","year":"1973","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090209"},{"key":"e_1_2_1_7_2","first-page":"325","article-title":"Circulating haematopoietic progenitors in myelofibrosis","volume":"31","author":"Partensen S","year":"1981","journal-title":"Scand J Haematol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb02924.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1182\/blood.V68.1.134.134","article-title":"3A1 (CD7) expression precedes T \u03b2 gene rearrangement in precursor T (lymphoblastic) neoplasms","volume":"68","author":"Pittaluga S","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830320310"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1182\/blood.V73.2.381.381","article-title":"CD7+, CD4\u2010, CD8\u2010 acute leukemia: A syndrome of malignant pluripotent lymphohematopoietic cells","volume":"73","author":"Kurtzberg J","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830400205"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90142-V"},{"key":"e_1_2_1_14_2","first-page":"10","article-title":"Antigen analysis of hematopoiesis. 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