{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T10:08:03Z","timestamp":1777198083330,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the possible role of inadequate food intake in the pathogenesis of the growth retardation of patients with sickle cell anemia, we determined the daily intake of calories and macronutrients and measured several anthropometric indices in 20 patients with sickle cell anemia aged 17\u201335 years and in 15 of their normal siblings of similar age. Compared to the control groups, the male patients, but not the females, had a significantly lower mean weight, body mass index, midarm circumference, and triceps and subscapular skinfold thicknesses. Also, while the male patients consumed significantly less total calories, proteins, carbohydrates, and fats per day than their control group, no difference was noted between the daily intake of calories or macronutrients in the female patients and their control group. However, when the intake of calories and macronutrients was corrected for body weight, there was no statistically significant difference between the intake of nutrients in the male patients and their control subjects or between the female patients and their control group. These results suggest a sex\u2010related difference in the somatic growth of adolescent and adult patients with sickle cell anemia and also suggest that, although an inadequate food intake may be partly responsible for the impaired somatic growth in sickle cell anemia, other factors are also probably important. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830440302","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:26:33Z","timestamp":1172064393000},"page":"149-154","source":"Crossref","is-referenced-by-count":30,"title":["Growth retardation in homozygous sickle cell disease: Role of calorie intake and possible gender\u2010related differences"],"prefix":"10.1002","volume":"44","author":[{"given":"Onyechi","family":"Modebe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella A.","family":"Ifenu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407053110102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1966.02090080075005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0022-3476(80)80557-9","article-title":"Pre\u2010 and postnatal growth and development in sickle cell anemia","volume":"96","author":"Kramer MS","journal-title":"J Pediatr"},{"key":"e_1_2_1_5_2","first-page":"337","article-title":"Anthropometric status of sickle cell anemia patients in Lagos Nigeria","volume":"9","author":"Lesi FEA","year":"1979","journal-title":"Nigerian Med J"},{"key":"e_1_2_1_6_2","first-page":"355","article-title":"Growth status of children with sickle cell anemia","volume":"102","author":"Whitten CF","year":"1961","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_7_2","first-page":"429","article-title":"Heights and weights of Jamaican children with homozygous sickle cell anaemia","volume":"49","author":"Lowry MF","year":"1977","journal-title":"Hum Biol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.47.254.519"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-367"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1001\/jama.1976.03260480016021","article-title":"Trace elements in sickle cell disease","volume":"235","author":"Prasad AS","year":"1976","journal-title":"JAMA"},{"key":"e_1_2_1_11_2","first-page":"542","article-title":"Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia","volume":"94","author":"Chiu D","year":"1979","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198404001-00945"},{"issue":"1","key":"e_1_2_1_13_2","first-page":"30A","article-title":"Reduced total cholesterol (TC), high density (HDL) and low density (LDL) lipoproteins in patients with sickle cell anemia (SCA)","volume":"54","author":"Lubin B","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91677-0"},{"key":"e_1_2_1_15_2","first-page":"105","article-title":"Xylose absorption and disposition in adult Igbos with sickle cell anemia in Eastern Nigeria","volume":"2","author":"Obi GO","year":"1990","journal-title":"Orient J Med"},{"key":"e_1_2_1_16_2","first-page":"103","article-title":"Studies in sickle cell anemia\u2014Preliminary observations on gastrointestinal digestion and absorption","volume":"69","author":"Rahbar F","year":"1977","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0770093"},{"key":"e_1_2_1_18_2","volume-title":"The Assessment of Nutritional Status of the Community","author":"Jelliffe DB","year":"1966"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00017285-197503000-00004"},{"key":"e_1_2_1_20_2","first-page":"13","article-title":"Validity of the 24\u2010hour recall: Analysis of data obtained from elderly subjects","volume":"66","author":"Madden JP","year":"1975","journal-title":"J Am Diet Assoc"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/37.1.139"},{"key":"e_1_2_1_22_2","unstructured":"PlattBS:Tables of Representative Values of Foods Commonly Used in Tropical Countries. 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