{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:45:55Z","timestamp":1790419555354,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4605,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine whether warm\u2010antibody autoimmune hemolytic anemia (AIHA) responds to treatment with intravenous gammaglobulin (IVGG), we conducted separate pilot studies at three institutions enrolling a total of 37 patients. We combined these results with a review of 36 cases of AIHA treated with IVGG reported in the literature. Sixteen clinical variables were examined to determine associations with response to IVGG. Overall, 29 of 73 patients (39.7%) responded to IVGG therapy. Two variables were strongly related to a good response to IVIG: the presence of hepatomegaly (with and without splenomegaly) and a low pre\u2010treatment hemoglobin. A trend towards a better response was observed in the 11 children. Overall, IVGG provided acute benefit in only 1\/3 of patients and therefore cannot be recommended as standard therapy for AIHA. It may, however, be useful as adjunctive treatment in selected cases, such as in those with a pre\u2010treatment hemoglobin &lt; 6\u20137 gm\/dl or those with hepatomegaly, and in clinical settings where the toxicity of other treatments may be an important consideration. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830440404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:51:25Z","timestamp":1172065885000},"page":"237-242","source":"Crossref","is-referenced-by-count":152,"title":["Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: Results in 73 patients"],"prefix":"10.1002","volume":"44","author":[{"given":"Glenn","family":"Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham\u2010Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Newland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0308-2261(21)00630-5","article-title":"Immune hemolytic disease: the autoimmune hemolytic anaemias","volume":"4","author":"Pirofsky B","year":"1975","journal-title":"Clin Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6281.2023"},{"key":"e_1_2_1_4_2","first-page":"147","article-title":"Factors influencing prognosis in childhood autoimmune hemolytic anemia","volume":"5","author":"Heiswel MA","year":"1983","journal-title":"Am J Ped Hem\/Oncol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92400-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.2.480.480"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91738-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb01266.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207223070420"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1182\/blood.V62.2.398.398","article-title":"Reversal of neutropenia with intravenous gammaglobulin in autoimmune neutropenia of infancy","volume":"62","author":"Bussel JB","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1986.tb01967.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90175-7"},{"key":"e_1_2_1_13_2","first-page":"41","article-title":"Utilization des gammaglobulines intraveneuses a fortes doses dans le traitement des anemies hemolytiques autoimmunes","volume":"12","author":"Bussel A","year":"1983","journal-title":"Nouv Presse Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07430.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80405-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062102"},{"key":"e_1_2_1_17_2","first-page":"577","article-title":"Intravenous immunoglobulin in immune thrombocytopenia","volume":"2","author":"Marmont AM","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb00767.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90344-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90106-4"},{"key":"e_1_2_1_21_2","first-page":"159","article-title":"Treatment of pure red cell aplasia by high dose intravenous gamma globulin","volume":"82","author":"Clauvel JP","year":"1987","journal-title":"Am J Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90544-4"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90398-6"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1988.tb01186.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1987.tb01228.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80252-9"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871201)60:11<2637::AID-CNCR2820601111>3.0.CO;2-S"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830250212"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1987.tb03029.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80074-X"},{"key":"e_1_2_1_31_2","first-page":"421","volume-title":"Hematology of Infancy and Childhood","author":"Schreiber AD","year":"1981"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1182\/blood.V77.9.1884.1884","article-title":"Intravenous anti\u2010D treatment of immune thrombocytopenia: Analysis of efficacy, toxicity, and mechanism of effect","volume":"77","author":"Bussel JB","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_33_2","first-page":"285","article-title":"Postsplenectomy sepsis","volume":"1","author":"Singer DB","year":"1973","journal-title":"Perspec Pediatr Pathol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-6-808"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830440404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830440404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:37:11Z","timestamp":1698237431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830440404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,12]]}},"alternative-id":["10.1002\/ajh.2830440404"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830440404","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,12]]}}}