{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:43:10Z","timestamp":1790772190327,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4543,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To examine recent changes in longevity and the causes of death among persons with hemophilia A, we evaluated death certificate data for persons who died in the United States from 1968 through 1989 and had hemophilia A or congenital Factor VIII disorder (ICD code 286.0) listed on the death certificate as one of the multiple causes of death. Multiple\u2010cause\u2010of\u2010death mortality data for the United States from 1968 to 1989 were examined to compare death rates by year, focusing on death rates and causes of death for 1979\u20101981, 1983\u20101985, and 1987\u20101989. Gender, age group, race, geographic region, and median age at death of persons with hemophilia A and human immunodeficiency virus (HIV)\u2010related disease listed as a cause of death were compared with those with hemophilia A without HIV\u2010related disease. From 1968 through 1989, 2,792 hemophilia A deaths were reported. The death rate increased from 0.5 to 1.3 per 1,000,000 persons. From 1979\u20101981 through 1987\u20101989, mortality increased in all age groups above 9 years of age and age at death shifted markedly to lower ages. Median age at death decreased from 57 years in 1979\u20101981 to 40 years in 1987\u20101989. The percentage of deaths due to hemorrhage or diseases of the circulatory system decreased markedly as the result of the increase in deaths associated with HIV infection or infections other than HIV infection. Spread of HIV\u20101 infection in persons with hemophilia A has disrupted the reduction in mortality seen with factor replacement therapy, implementation of home care, and use of comprehensive hemophilia treatment centers. It is hoped that advances in the care of HIV\u2010infected persons will improve survival in the hemophilia community. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:49:32Z","timestamp":1172065772000},"page":"112-121","source":"Crossref","is-referenced-by-count":63,"title":["Changes in longevity and causes of death among persons with hemophilia A"],"prefix":"10.1002","volume":"45","author":[{"given":"Terence L.","family":"Chorba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Holman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara W.","family":"Strine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Evatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1983.tb08595.x"},{"key":"e_1_2_1_3_2","volume-title":"National Blood Resource Program","author":"National Heart, Lung, and Blood Institute","year":"1972"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/203312a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/oxfordjournals.aje.a114051","article-title":"Acquired immunodeficiency syndrome among patients attending hemophilia treatment centers and mortality experience of hemophiliacs in the United States","volume":"121","author":"Johnson RE","year":"1985","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_6_2","first-page":"667","article-title":"Purification of human antihemophilic factor (factor VIII) by gel chromatography","volume":"221","author":"van Mourik JA","year":"1970","journal-title":"Biochem Biophys Acta"},{"key":"e_1_2_1_7_2","first-page":"185","article-title":"Isolation and some chemical properties of human factor VIII (antihemophilic factor)","volume":"77","author":"Hershgold EJ","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107022"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0021-9258(19)43824-6","article-title":"Isolation and characterization of human factor VIII (antihemophilic factor)","volume":"248","author":"Legaz ME","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107405"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/jama.1968.03140350023005","article-title":"A new high\u2010potency glycine\u2010precipitated antihemophilic factor (AHF) concentrate","volume":"205","author":"Brinkhous KM","year":"1968","journal-title":"JAMA"},{"key":"e_1_2_1_12_2","first-page":"365","article-title":"Pneumocystis carinii pneumonia among persons with hemophilia A","volume":"31","author":"Centers for Disease Control","year":"1982","journal-title":"MMWR"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.253.23.3409"},{"key":"e_1_2_1_14_2","unstructured":"Centers for Disease Control and Prevention: \u201cHIV\/AIDS Surveillance Report \u201d February pp1\u201323 1993."},{"key":"e_1_2_1_15_2","volume-title":"Vital Statistics Mortality Data, Multiple Cause Detail, 1969\u20101989, Public Use Data Tape Contents and Documentation Package","author":"Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics","year":"1992"},{"key":"e_1_2_1_16_2","volume-title":"Vital Statistics of the United States","author":"National Center for Health Statistics","year":"1991"},{"key":"e_1_2_1_17_2","volume-title":"Manual of the International Statistical Classicification of Diseases, Injuries, and Causes of Death","author":"World Health Organization","year":"1977"},{"key":"e_1_2_1_18_2","series-title":"Vital and Health Statistics Series 1. No. 20, DHHS Pub. No. (PHS) 86\u20101322. Public Health Service","volume-title":"TRANSAX, the NCHS system for producing multiple cause\u2010of\u2010death statistics, 1968\u201378","author":"National Center for Health Statistics","year":"1986"},{"key":"e_1_2_1_19_2","first-page":"161","article-title":"Analytical potential for multiple cause\u2010of\u2010death data. Am J","volume":"124","author":"Israel RA","year":"1986","journal-title":"Epidemiol"},{"key":"e_1_2_1_20_2","volume-title":"Intercensal Estimates of the Population of Counties by Age, Sex and Race: 1970\u20101990","author":"Bureau of Census","year":"1992"},{"key":"e_1_2_1_21_2","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"1986"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.82.4.561"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.77.2.148"},{"key":"e_1_2_1_24_2","first-page":"5","volume-title":"Nonparametrics: Statistical Methods Based on Ranks","author":"Lehmann EL","year":"1975"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830270103"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32893032095.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6810.1093"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.8.967"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-1-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910263211701"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.2307\/2532057"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1182\/blood.V64.3.715.715","article-title":"Immunologic status of hemophilia patients treated with cryoprecipitate or lyophilized factor concentrate","volume":"64","author":"Gjerset GF","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1182\/blood.V78.6.1623.1623","article-title":"Treatment type and amount influenced human immunodeficiency virus seroprevalence of patients with congenital bleeding disorders","volume":"78","author":"Gjerset GF","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208063270601"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25686071421.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830230315"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92288-X"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.266.20.2861"},{"key":"e_1_2_1_39_2","first-page":"1","article-title":"Interpretation and use of the Western blot assay for serodiagnosis of human immunodeficiency virus type 1 infections","volume":"38","author":"Centers for Disease Control","year":"1989","journal-title":"MMWR"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31191096183.x"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910053211405"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208063270610"},{"key":"e_1_2_1_43_2","first-page":"805","article-title":"Transfusion\u2010associated AIDS cases in Europe: Estimation of the incubation period distribution and prediction of future cases","volume":"4","author":"Downs AM","year":"1991","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_44_2","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1096\/fasebj.5.10.2065886","article-title":"HIV epidemiology: Past, present, and future","volume":"5","author":"Blattner WA","year":"1991","journal-title":"Faseb J"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802253180803"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28588337347.x"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198905043201803"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012133232417"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90836-7"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92264-0"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890060203"},{"key":"e_1_2_1_52_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/blood.V76.1.254.254","article-title":"The prevalence of antibody to hepatitis C in a cohort of hemophilic patients","volume":"76","author":"Bretler DB","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911303212202"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90055-8"},{"key":"e_1_2_1_55_2","first-page":"335","article-title":"Current safety of clotting factor concentrates","volume":"114","author":"Epstein JS","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_56_2","first-page":"161","volume-title":"Recent Advances in Hemophilia Care","author":"Fricke WA","year":"1990"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.2.254"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.9.2494.2494"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-8-641"},{"key":"e_1_2_1_60_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/oxfordjournals.aje.a114657","article-title":"The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population","volume":"126","author":"McGrady GA","year":"1987","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_61_2","first-page":"1","article-title":"Human immunodeficiency virus infection in the United States: A review of current knowledge","volume":"36","author":"Centers for Disease Control","year":"1987","journal-title":"MMWR"},{"key":"e_1_2_1_62_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-0038-1647263","article-title":"Azidothymidine (AZT) in the treatment of symptomatic HIV\u20101\u2010infected hemophiliacs","volume":"64","author":"Eichlinger S","year":"1990","journal-title":"Thrombosis Haemostasis"},{"key":"e_1_2_1_63_2","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1182\/blood.V78.4.900.900","article-title":"Placebo\u2010controlled trial to evaluate zidovudine in treatment of human immunodeficiency virus infection in asymptomatic patients","volume":"78","author":"Merigan TC","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_64_2","first-page":"120","article-title":"The effect of antiviral therapy on the natural history of human immunodeficiency virus infection in a cohort of hemophiliacs","volume":"5","author":"Ragni MV","year":"1992","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_65_2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jama.1992.03480090080031","article-title":"Survival of zidovudine\u2010treated patients with AIDS compared with that of contemporary untreated patients","volume":"267","author":"Vella S","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261601"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.253.5017.263"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830450204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830450204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:25:42Z","timestamp":1695774342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830450204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1002\/ajh.2830450204"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830450204","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}