{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T20:48:07Z","timestamp":1726260487254},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4543,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemorrhage in a patient with factor VIII inhibitor is associated with increased morbidity and mortality. Treatment with factor IX complex concentrates or recombinant factor VIIA (rVIIa) may not control bleeding and may induce thrombosis. In this study, continuous infusion of a monoclonal antibody\u2010purified factor VII concentrate (Monoclate\u2010P) was used successfully in two hemophilic patients with factor VIII alloantibodies and one nonhemophilic patient with a factor VIII autoantlbody. In two patients, hemorrhage was life\u2010threatening, and, in one, bleeding did not stop with repeated infusions of activated factor IX complex concentrates. The patients' ages ranged from 4 to 15 years, and the inhibitor levels from 6 to 300 Bethesda units\/ml. Clinical hemostasis was excellent, and In vivo recovery of infused factor VIII was achieved. When an excess of monoclonal factor VIII was added to the inhibitor plasma in vitro, a stable level of residual factor VIII activity was noted after an initial rapid loss. This second\u2010order reaction occurs in plasmas of patients with type I factor VIII inhibitors. In one patlent, we showed that the saturation dose of the factor VIII inhibitor predicted in vivo recovery of factor VIII:C. These data emphasize the importance of characterizing the kinetic reactions of the factor VIII inhibitor. Furthermore, we confirm previous reports that continuous infusion of monoclonal factor VIII is a safe and effective treatment of patients with factor VIII inhibitors in whom hemorrhage Is either life\u2010threatening or refractory to standard treatment. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:49:32Z","timestamp":1172065772000},"page":"142-145","source":"Crossref","is-referenced-by-count":12,"title":["Continuous infusion of monoclonal antibody\u2010purified factor VIII: Rational approach to serious hemorrhage in patients with allo\u2010\/autoantibodies to factor VIII"],"prefix":"10.1002","volume":"45","author":[{"given":"Erlinda M.","family":"Gordon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Al\u2010Batniji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C.","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"57","article-title":"Treatment of factor VIII inhibitors","volume":"9","author":"Kasper CK","year":"1989","journal-title":"Progr Hemostas Thromb"},{"issue":"6","key":"e_1_2_1_3_2","first-page":"3","article-title":"Thrombogenicity associated with factor IX complex concentrates","volume":"28","author":"Lusher JM","year":"1991","journal-title":"Semin Hematol"},{"key":"e_1_2_1_4_2","first-page":"6348","article-title":"Experiences with recombinant factor VIIa in haenophiliacs","volume":"58","author":"Hender U","year":"1991","journal-title":"Curr Stud Hematol Blood Transfus"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360311"},{"key":"e_1_2_1_6_2","first-page":"27","article-title":"The preclinical characterization of Monoclate factor VIII: C antihemophilic factor human","volume":"25","author":"Schreiber AB","year":"1988","journal-title":"Semin Hematol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657018"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651380"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1182\/blood.V44.3.313.313","article-title":"Antibodies to factor VIII: Specificity and kinetics of iso\u2010 and hetero\u2010antibodies in hemophilia A","volume":"44","author":"Allain JP","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199302000-00015"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030803"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109243051301"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1182\/blood.V62.5.1135.1135","article-title":"Autoplex versus Proplex: A controlled, double\u2010blind study of effectiveness in hemophiliacs with inhibitors to factor VIII","volume":"62","author":"Lusher JM","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(91)80145-C"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804143181503"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-0038-1657295","article-title":"Disseminated intravascular coagulation after infusion of FEIBA (factor VIII inhibitor by\u2010passing activity) in a patient with acquired hemophilia","volume":"48","author":"Rodeghiero F","year":"1982","journal-title":"Thromb Haemostas"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307283090413"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830450209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830450209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:26:01Z","timestamp":1695774361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830450209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1002\/ajh.2830450209"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830450209","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}