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The CD21 antigen was expressed by one of the eight cases of neoplastic lymphoid cells expressing the CD7 antigen as a sole pan\u2010T antigen, by three of the 20 cases of pro\u2010 or early thymic stage (CD7+ CD5+ CD2\u2010, CD7+ CD5\u2010 CD2+, or CD7+ CD5+ CD2+), and ten of 11 cases of thymic stage (CD3r CD4+ CD8+), but not by one case of late thymic stage (CD3 \u00b1 CD4+ CD8\u2010) T\u2010ALULBL cells. The CD21 antigen was not expressed by any of the 11 cases of adult T\u2010cell leukemia (ATL) or two cases of chronic T\u2010lineage leukemia. At most 4% of the normal thymocytes obtained from seven infants or children expressed the CD21 antlgen. While only a very limited population of normal thymocytes expresses CD21 antigen, T\u2010ALL\/LBL cells at the thymic stage characteristically express CD21 antigen in contrast to pro\u2010 or early thymic ALL\/LBL or peripheral\u2010stage neoplastic T cells. The estimation of the expression of CD21 antigen is useful for delineating stages of differentiation in T\u2010ALL\/LBL. Furthermore, these observation are notable, considering the possibiilty that the reported EBV\u2010carrying T\u2010cell lymphomas result from the penetration of EBV into EBV\u2010negative neoplastic T cells. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450211","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:49:32Z","timestamp":1172065772000},"page":"150-155","source":"Crossref","is-referenced-by-count":7,"title":["CD21 antigen in T\u2010lineage neoplastic lymphoid cells: Characteristic expression at thymic stage"],"prefix":"10.1002","volume":"45","author":[{"given":"Eiji","family":"Tatsumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1365"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/jvi.22.3.816-821.1977","article-title":"Presence of Epstein\u2010Barr virus receptors, but absence of virus penetration in cells of an Epstein\u2010Barr virus genome\u2010negative human 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