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Bone marrow aspirate showed the proliferation of large atypical cells, some of which exhibited phagocytic activity. At postmortem examination, there was diffuse infiltration of these atypical cells In the liver, spleen, kidney, and bone marrow. Morphological, cytochemlcal, immunohistochemlcal, and genotypic characteristics suggested that the proliferating cells were derived from the monocyte\u2010rnacrophage system. Western blot analysis revealed the presence of autoantibody against an \u223c88 kd molecule of platelet proteins. Although the relationship of cause and effect remains to be clarified, this autoantibody appeared to have stimulated thrombophagocytosls of the neoplastic cells. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:48:55Z","timestamp":1172065735000},"page":"244-247","source":"Crossref","is-referenced-by-count":3,"title":["Malignant histiocytosis associated with autoimmune 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