{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:40:52Z","timestamp":1777531252789,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4515,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic hypereosinophilic syndrome (HES) is a poorly understood disorder characterized by a markedly elevated peripheral blood eosinophil count in the absence of known associated causes of hypereosinophilia. Idiopathic hypereosinophilic syndrome is associated with eosinophil\u2010induced organ damage, including endomyocardial and pulmonary fibrosis, stroke, and gastrointestinal disease. Treatment of idiopathic HES is centered on the reduction of peripheral circulating eosinophils in an effort to diminish tissue infiltration and destruction. Multiple cytotoxic agents have been tried, with variable resutts. Prednisone and hydroxyurea have remained the therapies of choice in long term treatment of idiopathic HES. We report here the successful 2 year treatment of aggressive idiopathic HES, refractory to hyroxyurea and prednisone, with \u03b1\u2010interferon. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450311","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:48:55Z","timestamp":1172065735000},"page":"248-251","source":"Crossref","is-referenced-by-count":26,"title":["\u03b1\u2010Interferon treatment for idiopathic hypereosinophilic syndrome"],"prefix":"10.1002","volume":"45","author":[{"given":"Paula L.","family":"Bockenstedt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Santinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven F.","family":"Bolling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-2-167"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1982.tb02339.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.6.601"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1958.7.100"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62384-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205289"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840915)54:6<1058::AID-CNCR2820540621>3.0.CO;2-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90135-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-77-2-223"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90053-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206350"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910601)67:11<2826::AID-CNCR2820671119>3.0.CO;2-#"},{"key":"e_1_2_1_14_2","first-page":"178","article-title":"Effective therapy for a severe case of the idiopathic hypereosinophilic syndrome","volume":"11","author":"Marshall GM","year":"1989","journal-title":"Am J Pediatric Hematol Oncol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90055-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64701-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0022-5223(19)38769-0","article-title":"Mitral valve replacement in idiopathic hypereosinophilic syndrome","volume":"89","author":"Blake DP","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)91034-S"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90929-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.4049\/jimmunol.145.9.2950","article-title":"Effects of IFN on human eosinophils in comparison with other cytokines","volume":"145","author":"Valerius T","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-4-338_2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-9-716"},{"key":"e_1_2_1_23_2","first-page":"258","article-title":"Alpha\u2010interferon in a case of hypereosinophilic syndrome","volume":"76","author":"Van Den Anker\u2010Lugtenburg PJ","year":"1990","journal-title":"Br J Haematol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07811.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830450311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830450311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:58:27Z","timestamp":1698112707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830450311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1002\/ajh.2830450311"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830450311","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}