{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:27:40Z","timestamp":1756312060367},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4484,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present investigation evaluated the serum transferrin receptor concentration in subjects with nontransfusional iron overload who were identified in two separate studies on the basis of a serum ferritin level above 400 \u03bcg\/L. Subjects with preciinical hereditary hemochromatosis were evaluated in the first study and those with the African form of iron overload in the second. in the first study, hereditary hemochromatosis was identified in 14 white men on the basis of a persistent elevation in transferrin saturation above 55%. The serum receptor concentration was elevated above the upper cut\u2010off of 8.5 mg\/L in two of the subjects, but the mean receptor of 6.1 \u00b1 1.4 mg\/L (mean \u00b1 2 SE) did not differ significantly from the normal mean for this assay of 5.6 \u00b1 0.3 mg\/L. In the same study, 60 control subjects with secondary iron overload were identified on the basis of a serum ferritin persistently above 400 \u03bcg\/L, with a normal serum C\u2010reactive protein concentration but with a transferrin saturation &lt;55%. Three of these subjects had an elevated serum receptor concentration but the mean value of 5.5 \u00b1 0.4 mg\/L did not differ from normals nor from subjects with hemochromatosis. In the second study, 49 black Africans with iron overload were divided into those with or without an elevated transferrin saturation. The mean serum receptor concentration of 5.0 \u00b1 0.8 mg\/L and 4.5 \u00b1 0.4 mg\/L, respectively, did not differ statistically. It was concluded that there is no evidence of generalized dysreguiation of the transferrin receptor in hemochromatosis or African siderosis. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830450404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:47:32Z","timestamp":1172065652000},"page":"288-292","source":"Crossref","is-referenced-by-count":14,"title":["Serum transferrin receptor in hereditary hemochromatosis and African siderosis"],"prefix":"10.1002","volume":"45","author":[{"given":"Roy D.","family":"Baynes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Bothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo E.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1433","volume-title":"The Metabolic Basis of Inherited Disease","author":"Bothwell TH","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00178.x"},{"key":"e_1_2_1_4_2","first-page":"479","article-title":"Distribution of storage iron as body stores expand in patients with hemochrornatosis","volume":"86","author":"Valberg LS","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113868"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0016-5085(89)91625-9","article-title":"Immunohistochemical evidence for a lack of femtin in duodenal absorptive epithelial cells in idiopathic hemochromatosis","volume":"96","author":"Francanzani AL","year":"1989","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90161-Q"},{"key":"e_1_2_1_8_2","first-page":"24","article-title":"Iron absorption. 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