{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:50:43Z","timestamp":1698213043526},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4454,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objectives: To assess relationships among the effects of HIV on hemophilic children and adolescents' immunologic parameters and vaccine\u2010related serology.<\/jats:p><jats:p>Methods: We analyzed data from extensive baseline immunologic evaluations of 207 HIV antibody\u2010positive (HIV+) and 126 HIV antibody\u2010negative (HIV\u2212) hemophilic children and adolescents.<\/jats:p><jats:p>Results: HIV+ and HIV\u2010 participants differed significantly in T\u2010lymphocyte subpopulation numbers, immunoglobulin levels, and seroprevalence rates for diphtheria toxoid, measles, and mumps antigens. IgG levels, IgM levels, and serologic titers to vaccine antigens showed little correlation with T\u2010cell parameters. Proportionately more HIV+ participants were nonreactive to each and all of a panel of 7 skin test antigens (71 % vs 28% anerglc, RR 2.6). The odds of anergy increased 1.6 times for every decline of 200 CD4 \u00b1 cells\/\u03bcTl.<\/jats:p><jats:p>Conclusions: HIV had significant, largely independent T\u2010 and B\u2010lymphocyte effects on this pediatric cohort. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:46:34Z","timestamp":1172065594000},"page":"29-35","source":"Crossref","is-referenced-by-count":12,"title":["Immune and serologic profiles of HIV\u2010infected and noninfected hemophilic children and adolescents"],"prefix":"10.1002","volume":"46","author":[{"given":"Janine","family":"Jason","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Evatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn A.","family":"Sleeper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyne M.","family":"Donfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Gomperts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199305000-00009"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1542\/peds.82.4.565","article-title":"HIV infection in hemophiliac children","volume":"82","author":"Jason J","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","first-page":"277","article-title":"HIV and hemophilic children's growth","volume":"2","author":"Jason JM","year":"1989","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910263211701"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.8.967"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860030507"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830340406"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(89)90193-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90097-A"},{"key":"e_1_2_1_11_2","first-page":"75","article-title":"Multitest CMI for standardized measurement of delayed cutaneous hypersensitivity and cell\u2010mediated immunity. 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