{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:21:22Z","timestamp":1782296482769,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4454,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty one patients with sickle cell disease admitted to the hospital with the pain of vaso\u2010occlusive crisis (VOC) were treated by continuous IV infusion of ketorolac or normal saline for up to 5 days. All patients received supplemental IM injections of meperidine, 100 mg, as necessary, but not more frequently than every 3 hr. Over the 5 days the ketorolac treated patients (KT) required 33% less meperidine than did the placebo treated patients (PL), <jats:italic>P<\/jats:italic> = 0.04, and had significantly better pain relief as assessed by categorical, visual analog, and pain relief scales. By the end of 5 days infusions had been discontinued in six KT and one PL. The time to discontinuation of the infusion was significantly shorter in KT, (<jats:italic>P<\/jats:italic> = 0.009). The median duration of hospital stay from the start of treatment was 3.3 days for KT and 7.2 days for PL, <jats:italic>P<\/jats:italic> = 0.027. Adverse events were mainly related to the digestive system. This study showed that continuous infusion of ketorolac significantly reduced total meperidine requirement and that the analgesia produced by this combination was superior to that produced by meperidine alone. Further evaluation of this drug in the management of sickle cell VOC is warranted. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:46:34Z","timestamp":1172065594000},"page":"43-47","source":"Crossref","is-referenced-by-count":57,"title":["Enhancement of pain control with ketorolac tromethamine in patients with sickle cell vaso\u2010occlusive crisis"],"prefix":"10.1002","volume":"46","author":[{"given":"Elliott","family":"Perlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Burt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Ruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McHugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Advances in Pain Research and Therapy","author":"Benjamin LJ","year":"1991"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-5-364"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/42.2.113"},{"key":"e_1_2_1_5_2","first-page":"764","article-title":"Meperidine\u2010induced seizures in sickle cell patients","volume":"15","author":"Tang RS","year":"1980","journal-title":"Hosp Formul"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199001000-00003"},{"key":"e_1_2_1_7_2","first-page":"113","article-title":"Infusional\/patient controlled analgesia in sickle cell vaso\u2010occlusive crises","volume":"6","author":"Perlin E","year":"1993","journal-title":"The Pain Clinic"},{"key":"e_1_2_1_8_2","first-page":"254","article-title":"Treatment of sickle cell pain crisis: A clinical trial of diflunisal (Dolobid)*","volume":"25","author":"Perlin E","year":"1988","journal-title":"Clin Trials J"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199039010-00008"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1987.71"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1990.tb03579.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1986.tb03485.x"},{"key":"e_1_2_1_13_2","unstructured":"UdeaniG KoshyM DomL:Intramuscular ketorolac tromethamine in the treatment of painful episodes in sickle cell disease. Presented at the 16th Ann Conf Natl Sickle Cell Dis Prog Mobile Alabama 1991."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)82929-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90656-A"},{"key":"e_1_2_1_16_2","unstructured":"GriffinTC MorrisonR McBrideD McIntyreD BuchananGR:High\u2010dose methylprednisolone shortens the duration of painful episodes requiring hospitalization in children with sickle cell disease: Results of a randomized placebo\u2010controlled double\u2010blind trial. Presented at the 17th Ann Conf Natl Sickle Cell Disease Program Nashville Tennessee 1992."}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830460108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830460108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T13:21:46Z","timestamp":1698153706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830460108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1002\/ajh.2830460108"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830460108","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}