{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T14:00:48Z","timestamp":1718460048870},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4423,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes. The lesions resolved following antifungal therapy, but persisting pancytopenia and splenomegaly necessitated further hematological evaluation. A diagnosis of HCL was suspected based on morphologically characteristic hairy cells in the peripheral blood that contained tartrate resistant acid phosphatase. A bone marrow biopsy specimen had a normocellular marrow with an increase in interstitial lymphoid cells that stained with L26, MB2, and LN2 antibodies. On flow cytometry these cells were positive for the leukocyte common antigen, B cell markers, and the CD11c antigen confirming the diagnosis of HCL. We believe that this is the first report of sporotrichosis infection as a presenting manifestation of HCL. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460214","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:43:41Z","timestamp":1172065421000},"page":"134-137","source":"Crossref","is-referenced-by-count":5,"title":["Sporotrichosis as a presenting manifestation of hairy cell leukemia"],"prefix":"10.1002","volume":"46","author":[{"given":"Shimareet","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Gourley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack B.","family":"Alperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V53.3.412.412"},{"key":"e_1_2_1_3_2","first-page":"458","article-title":"Hairy cell leukemia: Clinical presentation and follow\u2010up of 211 patients","volume":"11","author":"Flandrin G","year":"1984","journal-title":"Semin Oncol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.6.876"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160410"},{"key":"e_1_2_1_6_2","first-page":"514","article-title":"Clinical problems in hairy cell leukemia: Diagnosis and management","volume":"11","author":"Westbrook CA","year":"1984","journal-title":"Semin Oncol"},{"key":"e_1_2_1_7_2","first-page":"288","article-title":"Unusual presentations and complications of hairy cell leukemia","volume":"1","author":"Bouroncle BA","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820501)49:9<1924::AID-CNCR2820490928>3.0.CO;2-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90259-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90634-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-1-23"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196705000-00002"},{"key":"e_1_2_1_13_2","volume-title":"Principles and Practices of Infectious Diseases","author":"Bennett JE","year":"1990"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-2-268_2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116354"},{"key":"e_1_2_1_16_2","volume-title":"Neoplastic Hematopathology","author":"Bitter MA","year":"1992"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1182\/blood.V75.7.1525.1525","article-title":"Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia","volume":"75","author":"Trentin L","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_18_2","first-page":"334","article-title":"The diagnosis and differential diagnosis of hairy cell leukemia in bone marrow and spleen","volume":"11","author":"Burke JS","year":"1984","journal-title":"Semin Oncol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2207::AID-CNCR2820501038>3.0.CO;2-P"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830460214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830460214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:24:34Z","timestamp":1698132274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830460214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1002\/ajh.2830460214"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830460214","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}