{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:05:58Z","timestamp":1790813158352,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the expression of interleukin\u20102 receptors (IL\u20102R) in 60 adult patients with mature lymphoid neoplasms by flow cytometric analysis, using two monoclonal antibodies, anti\u2010Tac for IL\u20102R \u03b1\u2010chain (IL\u20102R\u03b1) and Mik\u2010\u03b2 for IL\u20102R \u03b2\u2010chain (IL\u20102R\u03b2). Among B\u2010cell malignancies, IL\u20102R\u03b1 was found in 13\/25 (52%) cases of chronic lymphocytic leukemia (CLL) and its variants, 3\/14 (21%) of a heterogenous group of non\u2010Hodgkin's lymphoma (NHL) and none of the plasma cell diseases. IL\u20102R\u03b2 was not observed in any of B\u2010cell neoplasms. IL\u20102R\u03b1 was more frequently expressed in CD11 b(+) B\u2010cell neoplasms than in CD11b(\u2010) (<jats:italic>P<\/jats:italic> &lt; 0.05). In T\u2010cell disorders, all three cases of adult T\u2010cell leukemia\/lymphoma expressed IL\u20102R\u03b1 but not IL\u20102R\u03b2. IL\u20102R\u03b2 was detected in 3\/8 cases of CLL and 2\/3 of NHL and none of these cases expressed IL\u20102R\u03b1. CD8(+) malignant T\u2010cells commonly displayed IL\u20102R\u03b2. These data indicate that the IL\u20102R\u03b1 and IL\u20102R\u03b2 in mature lymphoid neoplasms was expressed independently each other and was associated with the particular phenotypical characteristics of neoplastic cells, respectively. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:42:56Z","timestamp":1172065376000},"page":"179-183","source":"Crossref","is-referenced-by-count":44,"title":["Differential expression of interleukin\u20102 receptors (\u03b1 and \u03b2 chain) in mature lymphoid neoplasms"],"prefix":"10.1002","volume":"46","author":[{"given":"Kazunori","family":"Nakase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenkichi","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Tsudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1631559"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.1.223"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90097-S"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1201"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.5.645"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb08139.x"},{"key":"e_1_2_1_8_2","unstructured":"NakaseK KitaK KageyamaS TsujiK MiyanishiE MiwaH TanakaIZ ShirakawaS TanakaI AnazawaH TsutaniH KyoT DohyH KamadaN DoiS NasuK UchinoH: Clinical importance of interleukin\u20102 receptor alpha chain expression in acute leukemia.Cancer Detect Prev(in press)."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.1982"},{"key":"e_1_2_1_10_2","first-page":"89","article-title":"Phenotypic characterization and clinical evaluation of 15 patients with lymphoblastic lymphoma","volume":"48","author":"Kita K","year":"1985","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.567"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1182\/blood.V66.1.47.47","article-title":"Phenotypic analysis of acute lymphoblastic leukemia (ALL) cells which are classified as non\u2010T non\u2010B and negative for common ALL antigen","volume":"66","author":"Kita K","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_13_2","first-page":"222","article-title":"A novel phenotype (CD4+, Leu7+) in large granular lymphocyte leukemia; 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