{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:16:15Z","timestamp":1780420575431,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnancy in women with congenital coagulation factor deficiencies has been associated with adverse fetal outcomes. Recurrent spontaneous abortions, placental abruptions, and premature births are reported, the exact reasons for which are not clear, and management of such patients continues to be a challenge. We reviewed the outcome of four pregnancies in a patient with factor X deficiency, and looked at the effect of factor replacement therapy on pregnancy. Her first two pregnancies resulted in the birth of extremely premature babies at 21 and 25 weeks of gestation, both of which died in the neonatal period. The patient was treated with fresh frozen plasma for acute bleeding episodes during these pregnancies. In addition during her second conception she was given factor IX complex [Konyne] prophylactically, but only in the latter half of her pregnancy. During her next two pregnancies she was treated early on during pregnancy, with prophylactic replacement of factor X. She delivered healthy babies at 34 and 32 weeks of gestation, and they are both doing well. We therefore suggest possible mechanisms by which aggressive prophylactic factor support in a female with severe congenital coagulopathy, may improve on fetal outcome. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460315","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:42:56Z","timestamp":1172065376000},"page":"241-244","source":"Crossref","is-referenced-by-count":42,"title":["Congenital coagulopathies and pregnancy: Report of four pregnancies in a factor X\u2010deficient woman"],"prefix":"10.1002","volume":"46","author":[{"given":"Manjusha","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Hemostasis and Thrombosis in Obstetrics and Gynecology","author":"Greer IA","year":"1992"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198528010-00008"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196011172632004"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90852-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0038-1653533","article-title":"Congenital factor VII deficiency, two cases in children of cousins","volume":"21","author":"Heikinheimo R","year":"1969","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206513"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1964.tb00028.x"},{"key":"e_1_2_1_9_2","first-page":"29","article-title":"Prothrombin quick: A newly identified dysprothrombinemia","volume":"53","author":"Owen CA","year":"1978","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_10_2","first-page":"69","article-title":"Factor XI deficiency: Surgical and Obstetrics aspect","volume":"35","author":"Purcell G","year":"1970","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_2","first-page":"507","article-title":"Factor V deficiency in obstetrics","volume":"19","author":"Philips LL","year":"1962","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood.V28.1.34.34","article-title":"Factor XIII deficiency with severe hemorrhagic diathesis","volume":"28","author":"Fisher S","year":"1966","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90354-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1978.tb15605.x"},{"key":"e_1_2_1_15_2","first-page":"519","article-title":"Congenital hypofibrinogenemia and recurrent placental abruption","volume":"61","author":"Ness PM","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_16_2","first-page":"1043","article-title":"Involvement of coagulation and fibrinolysis in fertilization and implantation mechanisms","volume":"28","author":"Nakabayashi M","year":"1987","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1972.tb15789.x"},{"key":"e_1_2_1_18_2","first-page":"25","article-title":"Immunological application and implication of pregnancy proteins","volume":"17","author":"Lin TM","year":"1984","journal-title":"Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30294-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-6-766"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830460315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830460315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T02:13:30Z","timestamp":1698113610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830460315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/ajh.2830460315"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830460315","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}