{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:44:09Z","timestamp":1770504249354,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4362,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hundred eighty\u2010eight unselected consecutive patients with \u201cde novo\u201d myelodysplastic syndrome (MDS) were studied cytogenetically. They were subclassified as 4 refractory anemia with ringed sideroblasts (RARS), 67 refractory anemia (RA), 58 refractory anemia with excess of blasts (RAEB), 40 RAEB in transformation (RAEB\u2010t), and 19 chronic myelomonocytic leukemia (CMML). The overall incidence of chromosome abnormalities was 69%. The RAEB and RAEB\u2010t patients showed karyotypic changes, more often than RA and CMML (76% and 100% vs. 56% and 42%, respectively). The most frequent single anomaly was del(5)(q13\u2010q22q33) (22 cases), followed by monosomy 7 or del 7q (11 cases), del(11) (q14q23) (8 cases), trisomy 8 (4 cases). Complex karyotypes (defined by the presence of three or more structural or numerical abnormalities) were detected in 33 patients. With regard to the FAB classification, del (5)(q13q33) was associated with RA, and complex rearrangements with RAEB and RAEB\u2010t. Leukemic transformation occurred in 66 patients (46%), none with a normal karyotype or del(11)(q14q23) as single abnormality. In patients carrying 5q\u2010 alone, acute evolution correlated with proximal breakpoint localization, being found in no case with del(5)(q13q33) but in three out of four cases with del(5)(q22q33). Acute leukemia (AL) progression happened in all cases with complex rearrangements and monosomy 7 or del(7q). Two of the four trisomy eight patients evolved in AL. By using the Cox proportional hazard regression analysis it was demonstrated that the karyotype abnormality was a significant predictor of leukemic transformation (<jats:italic>P<\/jats:italic> &lt; 0.001). Patients with abnormal karyotypes without complex abnormalities had a survival (median survival 12 months) shorter than that of cases with only normal metaphases (median 83 months) (<jats:italic>P<\/jats:italic> &lt; 0.001); patients with a mixture of normal\/abnormal metaphases had a median survival of 31 months. The median survival for complex karyotypes was 7 months. Among cases with single defects, del(5)(q13q33) showed the best survival (64 months), mono\u2010 somy 7 and del (7q) the worst (7 months) (<jats:italic>P<\/jats:italic> &lt; 0.001). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830460404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:42:43Z","timestamp":1172065363000},"page":"270-277","source":"Crossref","is-referenced-by-count":41,"title":["Karyotype in myelodysplastic syndromes: Relations to morphology, clinical evolution, and survival"],"prefix":"10.1002","volume":"46","author":[{"given":"P.","family":"Bernasconi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. P.","family":"Alessandrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Boni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bonfichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Morra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Campagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Astori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb06188.x"},{"key":"e_1_2_1_3_2","first-page":"399","article-title":"Chromosome studies in human haematologic disease. II. Myelodysplastic syndromes","volume":"72","author":"Larripa I","year":"1987","journal-title":"Haematologica"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90016-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90258-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90021-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861215)58:12<2571::AID-CNCR2820581202>3.0.CO;2-O"},{"key":"e_1_2_1_8_2","first-page":"1721","article-title":"Refide novo myelodysplastic syndromes","volume":"67","author":"Yunis JJ","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1182\/blood.V70.6.1705.1705","article-title":"The 5q\u2010 abnormality","volume":"70","author":"Nimer SD","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295602"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.8.1424"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/52.1-2.203"},{"key":"e_1_2_1_14_2","unstructured":"Statistica Vol. I Quick CSS. In Statsoft Inc 2325 East 13th Street Tulsa OK 74104 1986\u20101991."},{"key":"e_1_2_1_15_2","volume-title":"An International System for Cytogenetic Nomenclature: Cytogenet and Cell Genetics","author":"Harnden DG","year":"1985"},{"key":"e_1_2_1_16_2","first-page":"263","volume-title":"Myelodysplastic Syndromes","author":"Bernasconi C","year":"1991"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1988.tb00880.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood.V67.6.1765.1765","article-title":"Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes","volume":"67","author":"Jacobs RH","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90048-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90193-E"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb01157.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07871.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90101-F"},{"key":"e_1_2_1_24_2","first-page":"566","article-title":"Clinical and prognostic implications of chromosome 5q deletions: 96 high resolution studied patients","volume":"5","author":"Pedersen B","year":"1991","journal-title":"Leukemia"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1182\/blood.V80.1.217.217","article-title":"Clonal analysis of myelodysplastic syndrome: Monosomy 7 is expressed in the myeloid lineage, but not in the lymphoid lineage as detected by fluorescent in situ hybridization","volume":"80","author":"Gerritsen WR","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1182\/blood.V76.6.1083.1083","article-title":"Chromosome aberrations and prognostic factors in therapy\u2010related myelodysplasia and acute non lymphocytic leukemia","volume":"76","author":"Pedersen\u2010Bjergaard J","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950160204"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(92)90098-R"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90208-P"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90089-7"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90040-9"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennet JM","year":"1982","journal-title":"Br J Haematol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","unstructured":"RodgerMP MorrisCM BosmaTJ BowenJA HiltonJM FitzgeraldPH: Basophils derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34.Blood(suppl. 1):192 1988.","DOI":"10.1182\/blood.V73.3.777.777"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb02981.x"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830280104"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90002-2"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60566-7"},{"key":"e_1_2_1_38_2","first-page":"277","article-title":"Genetic lesions in preleukemia","volume":"5","author":"Jacobs A","year":"1991","journal-title":"Leukemia"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830460404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830460404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:38:53Z","timestamp":1696023533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830460404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1002\/ajh.2830460404"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830460404","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}