{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:55:42Z","timestamp":1761918942398},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4301,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We identified 22 women with thrombocytopenia of &lt;100,000\/\u03bcl found incidentally during pregnancy and prospectively monitored their platelet count and clinical outcome for a minimum of 6 months postpartum. During the study period, four women became pregnant twice, accounting for a total of 26 pregnancies. The lowest platelet count during pregnancy was 65,600\/\u03bcl \u00b1 19,400 (mean \u00b1 SD), and at delivery 84,500\/\u03bcl \u00b1 32,300 (<jats:italic>P<\/jats:italic> &lt; 0.02). The thrombocytopenia was virtually asymptomatic in all patients during the pregnancy and delivery, whether vaginal or surgical. Neonatal platelet counts (n = 18) were normal (270,700\/\u03bcl \u00b1 69,900), and none of the newborns (n = 24) had a bleeding diathesis. Normalization of the platelet count (i.e., &gt;150,000\/\u03bcl) was documented in 18 patients within 1 month postpartum, in five within 3 months postpartum, and in two as late as 5 months after delivery. One woman did not recover from the thrombocytopenia and eventually developed other stigmata of an autoimmune disease. Long\u2010term follow\u2010up showed recurrence of thrombocytopenia in four patients: three in the context of a subsequent pregnancy and one who developed idiopathic thrombocytopenic purpura. Retrospective analysis of blood counts obtained from 12 previous pregnancies demonstrated thrombocytopenia of a similar degree to the index pregnancy. We conclude that gestational thrombocytopenia of &lt;100,000\/\u03bcl is clinically a benign phenomenon that can recur in subsequent pregnancies and is not accompanied by neonatal thrombocytopenia. In some cases, however, pregnancy\u2010associated thrombocytopenia may be a manifestation of an autoimmune disease with its attendant implications for the neonate. Since the differential diagnosis between the two conditions may be difficult to establish when first encountered during pregnancy, a conservative approach emphasizing careful surveillance and guarded reassurance is justified as long as the platelet counts are &gt;50,000\/\u03bcl. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830470210","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:59:21Z","timestamp":1172066361000},"page":"118-122","source":"Crossref","is-referenced-by-count":16,"title":["Clinical relevance of gestational thrombocytopenia of &lt;100,000\/\u03bcl"],"prefix":"10.1002","volume":"47","author":[{"given":"Eyal","family":"Anteby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Shalev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807213190304"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90996-K"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830210408"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90475-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205022"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90634-4"},{"key":"e_1_2_1_8_2","volume-title":"Medical Diseases During Pregnancy","author":"Letsky E","year":"1991"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01443.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230409"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198611000-00017"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230404"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1182\/blood.V80.11.2697.2697","article-title":"Pregnancy\u2010associated thrombocytopenia: Pathogenesis and management","volume":"80","author":"McCrae KR","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311113292005"},{"key":"e_1_2_1_15_2","first-page":"238","article-title":"Autoimmune disorders and pregnancy","volume":"15","author":"Varner MW","year":"1991","journal-title":"Semin Perinatol"},{"key":"e_1_2_1_16_2","first-page":"387","volume-title":"Platelet Immunology","author":"Aster RH","year":"1989"},{"key":"e_1_2_1_17_2","first-page":"270a","article-title":"Platelet antibody determinations in ITP during pregnancy compared to gestational thrombocytopenia","volume":"82","author":"Bussel J","year":"1993","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830470210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830470210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:57:48Z","timestamp":1695880668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830470210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/ajh.2830470210"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830470210","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}