{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:53:57Z","timestamp":1697219637661},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4301,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM<jats:sub>2<\/jats:sub> has been mapped to this chromosome, we examined the possible association of MDM<jats:sub>2<\/jats:sub> in the pathogenesis of CLL. A rearrangement of the MDM<jats:sub>2<\/jats:sub> gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Southern biot hybridization. Expression of MDM<jats:sub>2<\/jats:sub> was detected in all of the CLL samples examined by Northern blot. However, neither gross amplification nor overexpression of the MDM<jats:sub>2<\/jats:sub> gene was found in CLL. The data suggest that MDM<jats:sub>2<\/jats:sub> may play a role in the pathogenesis of CLL and may help to explain how abnormalities of chromosome 12 are related to CLL. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830470215","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:59:21Z","timestamp":1172066361000},"page":"139-141","source":"Crossref","is-referenced-by-count":10,"title":["Rearrangement and expression of MDM<sub>2<\/sub> oncogene in chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"47","author":[{"given":"Yao Qi","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aby","family":"Buchbinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Gue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvin E.","family":"Friedman\u2010Kien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880801)62:3<500::AID-CNCR2820620310>3.0.CO;2-W"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009133231105"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/358080a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.1.301"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116279"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.6.1153.1153"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1182\/blood.V79.2.477.477","article-title":"Mutation of the p53 gene in adult T\u2010cell leukemia","volume":"79","author":"Sakashita A","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1073\/pnas.88.12.5413","article-title":"p53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia","volume":"88","author":"Gaidano G","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.9.2617.2617"},{"key":"e_1_2_1_11_2","first-page":"2736","article-title":"Amplification and overexpression of the MDM\u20102 gene in a subset of human malignant gliomas without p53 mutations","volume":"53","author":"Reigenberger G","year":"1993","journal-title":"Cancer Res"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830470215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830470215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:58:32Z","timestamp":1695880712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830470215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/ajh.2830470215"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830470215","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}