{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:19Z","timestamp":1761058639219},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixty\u2010two G6PD deficient Chinese males have been investigated for the presence of seven mutations of the coding region of the G6PD gene by natural and artifically created amplified restriction sites. The results show that the G to T substitution at nucleotide (nt) 1376 and G to A substitution at nt 1388 represent 24% and 21% of G6PD deficiency, respectively, in the Singapore Chinese; 37% of the sample could not be characterised. The remaining samples were identified as follows: 10% C\u2192T at nt 563, 5% A\u2192G at nt 95, and 3% C\u2192T at nt 1024. The G to A substitution (nt 487) and the substitution A\u2192G (nt 493) were not present in this sample. None of the subjects with the Mediterranean mutation (563 C\u2192T) had the silent mutation at 1311 (C\u2192T). This study confirms the extreme molecular heterogeneity of the G6PD gene in the Chinese. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830470405","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:58:10Z","timestamp":1172066290000},"page":"273-277","source":"Crossref","is-referenced-by-count":7,"title":["Molecular characterisation of red cell glucose\u20106\u2010phosphate dehydrogenase deficiency in Singapore Chinese"],"prefix":"10.1002","volume":"47","author":[{"given":"S.","family":"Saha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S. 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