{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:28:59Z","timestamp":1791167339304,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous lymphoma is a disease characterized with massive skin infiltration of lymphoid malignant cells. They commonly express some T\u2010cell markers, such as CD2, CD3, CD4, and CD7, and thus termed as CTCL (cutaneous T cell lymphoma). Here, we present a case with CD56\/N\u2010CAM\u2010positive cutaneous lymphoma, which appears lymphocytic morphology and expresses CD4, but does not express CD2, CD3, CD8, CD14, CD16, CD57, and CD20. The most malignant cells contained no distinctive azurophilic granules in the cytoplasm. Southern blot analysis revealed that T cell receptor\u2010\u03b2, \u03b3, and immunoglobulin heavy chain genes in the cells were in germ\u2010line configurations. Electron microscopic examination showed characteristics of lymphoid cells with higher nucleocytoplasmic ratio and lacked structures typical of other cell types (i.e., epithelial cells, neuroendocrine cells, and mesenchymal cells). Thus, the cells are likely to be immature lymphoid cells. Histological analysis revealed the cells infiltrate mainly into the dermis with angiocentric growth pattern. The clinical course was aggressive, with rapid involvement of bone marrow and central nervous system. These striking features of the patient may represent a novel fraction (CD2\u2212, CD4+, and CD56+) of cutaneous lymphoma. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830470406","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:58:10Z","timestamp":1172066290000},"page":"278-282","source":"Crossref","is-referenced-by-count":131,"title":["High expression of CD56 (N\u2010CAM) in a patient with cutaneous CD4\u2010positive lymphoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Masaaki","family":"Adachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuhiro","family":"Takekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hinoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohzoh","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105283042202"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.9.2432.2432"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90350-C"},{"key":"e_1_2_1_5_2","first-page":"725","article-title":"Report of the committee on staging and classification of cutaneous T\u2010cell lymphomas","volume":"63","author":"Bunn PA","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_6_2","first-page":"1300","article-title":"Expression of the natural killer cell\u2010associated antigens CD56 and CD57 in human neural muscle cells and in their tumors","volume":"51","author":"Mechtersheimer G","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.4049\/jimmunol.130.6.2947","article-title":"Characterization of an antigen expressed by human natural killer cells","volume":"130","author":"Griffin JD","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930101)71:1<249::AID-CNCR2820710138>3.0.CO;2-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1182\/blood.V72.5.1674.1674","article-title":"Angiocentric immunoproliferative lesions: A clinicopathologic spectrum of the post\u2010thymic T\u2010cell proliferations","volume":"72","author":"Lipford EH","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1182\/blood.V80.7.1717.1717","article-title":"CD4 is expressed on murine pluripotent hematopoietic stem cells","volume":"80","author":"Wineman JP","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood.V77.5.948.948","article-title":"Expression of intercellular adhesion molecule\u20101 (CD54) on hematopoietic progenitors","volume":"77","author":"Arkin S","year":"1991","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830470406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830470406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:49:07Z","timestamp":1698112147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830470406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/ajh.2830470406"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830470406","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}