{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:20:07Z","timestamp":1789096807407,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4150,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare benign disease of unknown etiology. It is rarely associated with malignant lymphoma. This report documents the first case of a T\u2010cell lymphoma, which developed in a patient with a 10\u2010year history of SHML. The disease was complicated by hypereosinophilia and massive retroperitoneal lymphadenopathy. Histological examination of a cervical lymph node biopsy during the terminal phase identified a lymphoma composed of cells with morphological plasmacytoid features. Ultrastructurally, the tumor cells showed poorly developed cytoplasm, nuclei with peripheral chromatin clumping, and inconspicuous nucleoli. Cytogenetic studies showed two related clones. On immunohistochemical staining tumor cells were positive with monoclonal antibodies (mAb) CD3 and CD45RO. Southern blotting analysis identified clonal rearrangements in the T\u2010cell receptor (TCR) alpha, beta and gamma genes. Thus, T\u2010cell lineage of the tumor cells was established. In situ hybridization of interleukin\u20102 (IL\u20102) and interleukin\u20105 (IL\u20105) cDNA probes on tissue sections identified the synthesis of IL\u20105 by the eosinophils, suggesting an autocrine pathway of eosinophilopoiesis leading to hypereosinophilia in this patient. \u00a91995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830480310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:56:18Z","timestamp":1172066178000},"page":"192-200","source":"Crossref","is-referenced-by-count":21,"title":["Morphological, ultrastructural, and genetic characterization of an unusual T\u2010cell lymphoma in a patient with sinus histiocytosis with massive lymphadenopathy"],"prefix":"10.1002","volume":"48","author":[{"given":"P. R. K.","family":"Koduru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Susin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Kolitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sonl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Teichberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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