{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:46:24Z","timestamp":1788461184397,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4089,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of CD45 RA\/RO antigen was investigated in neoplasms including cases expressing CD7 antigen as the sole pan\u2010T antigen (n = 8), T\u2010lineage acute lymphoblastic leukemia (ALL)\/lymphoblastic lymphoma (LBL) at various stages of differentiation (n = 32), peripheral stage T\u2010lineage leukemia (n = 10) and adult T\u2010cell leukemia (ATL) (n = 14). The p56<jats:sup>Ick<\/jats:sup> gene expression was also investigated in selected cases.<\/jats:p><jats:p>The expression pattern of CD45 RA\/RO antigen was defined as of RA, mixed, or RO type. All but one CD7+ CD5\u2212 CD2\u2212 case were of the RA type. The CD7+ CD5+ CD2\u2212 prothy\u2010mic stage included seven RA and one mixed type cases. One CD7+ CD5\u2212 CD2+ case was of the RA type, but the other was of the RO type. The CD7+ CD5+ CD2+ prothymic stage included three RA and four mixed type cases. All seven CD3\u2212 CD4+ CD8+ (double\u2010positive) thymic cases were of the RO type. The CD3+ CD4+ CD8+ (triple\u2010positive) stage included two RO and three mixed\u2010type cases. One CD3+ CD4+ CD8\u2212 late thymic case was of the mixed type. The peripheral stage cases included five RA, three RO, and two mixed type cases. All ATL cases were of the RO type. The expression of p56<jats:sup>Ick<\/jats:sup> gene in the prothymic stage was less marked than that in the thymic stage.<\/jats:p><jats:p>On the basis of these results, the following sequence of pattern of the CD45 RA\/RO antigen expression along with T\u2010lineage differentiation was reconstructed: prothymic stage [RA and mixed type] \u2192 double\u2010positive thymic stage [RO type] \u2192 triple\u2010positive thymic stage [RO and mixed type] \u2192 peripheral stage [RA, mixed, and RO type]. While one RO\u2010type CD7+ CD5\u2212 CD2\u2212 and one RO\u2010type CD7+ CD5\u2212 CD2+ cases were not in accord with this sequence, the pattern of CD45 RA\/RO antigen expression in most of T\u2010lineage neoplasms could be determined by the respective stage of differentiation. The poor expression of the p56<jats:sup>Ick<\/jats:sup> gene by the prothymic blasts compared with the thymic blasts may be related to the expression pattern of the CD45 RA\/RO molecules, which exhibits phosphatase activity. The consistent RO\u2010type expression in the ATL cases may reflect the activated status of the neoplastic T cells due to the presence of the HTLV\u2010I gene. Alternatively, the target cells for HTLV\u2010I\u2010induced neoplastic transformation may possibly be of the RO type. \u00a9 1995 Willey\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830490103","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:55:04Z","timestamp":1172066104000},"page":"6-14","source":"Crossref","is-referenced-by-count":9,"title":["Expression pattern of CD45 RA\/RO isoformic antigens in T\u2010lineage neoplasms"],"prefix":"10.1002","volume":"49","author":[{"given":"Seiji","family":"Kawano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.002011"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.4049\/jimmunol.141.8.2781","article-title":"Complete exon\u2010intron organization of the human leukocyte common antigen","volume":"141","author":"Hall LR","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"6220","DOI":"10.1016\/S0021-9258(18)83337-3","article-title":"Sequence conversion in potential regions of the mouse and human leukocyte common antigen gene","volume":"264","author":"Johnson NA","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.11.4889"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5364"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1548"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.4.399"},{"key":"e_1_2_1_9_2","first-page":"54","article-title":"Immunophenotyping of non\u2010Hogdkin's lymphomas using a panel of antibodies on paraffin embedded tissues","volume":"129","author":"Davey FR","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_2","first-page":"195","article-title":"Human T cell subsets","volume":"9","author":"Beverley PCL","year":"1988","journal-title":"Immunol Lett"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91212-1"},{"key":"e_1_2_1_12_2","article-title":"Phenotypic diversity of the CD45 antigen and its relationship to function","volume":"3","author":"Beverley PCL","year":"1988","journal-title":"Immunology 1 (Suppl)"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.19.7182"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00424a001"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6302"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.4.386"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/1.3.229"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830370106"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1182\/blood.V78.3.711.711","article-title":"Selective expression of CD45 isoform defines CALLA+ mono clonal B\u2010lineage cells in peripheral blood from myeloma patients as late stage B cells","volume":"78","author":"Jensen GS","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T\u2010cell leukemia: Clinical hematologic features of 16 cases","volume":"50","author":"Uchiyama T","year":"1977","journal-title":"Blood"},{"issue":"97","key":"e_1_2_1_21_2","first-page":"77","article-title":"Separation of leucocytes from blood and bone marrow","volume":"21","author":"Boym A","year":"1968","journal-title":"Scand J Clin Invest"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830450408"},{"key":"e_1_2_1_23_2","volume-title":"Leucocyte Typing 111. 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