{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:23:43Z","timestamp":1791779023456,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hematological and clinical features of 26 patients with myelodysplasia and a chromosome 5q deletion in the bone marrow are presented. We have examined the relationship of French\u2010American\u2010British Co\u2010operative Group (FAB) 1982 classification and bone marrow karyotype at diagnosis with patient outcome and the presence or absence of the classical features of the 5q\u2010 syndrome. Those patients classified as refractory anemia (RA) with no additional karyotypic abnormalities have the typical features of the 5q\u2010 syndrome and a good prognosis. None of the patients in this group transformed to acute leukemia during the period of follow\u2010up. Patients with either refractory anemia and excess blasts (RAEB) or additional karyotypic abnormalities show many of the hematologic features of the 5q\u2010 syndrome but do not share the good prognosis. We conclude that the 5q\u2010 syndrome may be best defined as primary MDS of the FAB type RA with a 5q deletion as the sole karyotypic abnormality. This simple definition will distinguish patients with a good prognosis and all the classical features of the 5q\u2010 syndrome.<\/jats:p>","DOI":"10.1002\/ajh.2830490304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:53:07Z","timestamp":1172065987000},"page":"194-200","source":"Crossref","is-referenced-by-count":28,"title":["Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion"],"prefix":"10.1002","volume":"49","author":[{"given":"S.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Oscier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Boultwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fitchett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Abrahamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Buckle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Wainscoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/251437a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood.V46.4.519.519","article-title":"A new hematological syndrome with a distinct karyotype: The 5q\u2010chromosome","volume":"46","author":"Sokal G","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90449-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90016-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1182\/blood.V48.4.624.624","article-title":"5q\u2010acute myeloid leukemia","volume":"48","author":"van den Berghe H","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_7_2","first-page":"626","article-title":"5q\u2010acute myeloid leukemia","volume":"48","author":"Rowley JD","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_8_2","first-page":"51","article-title":"Chromosome study of 85 patients with myelodysplastic syndrome","volume":"35","author":"Musilova J","year":"1987","journal-title":"Cancer Genet Cytogenet"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1182\/blood.V73.1.263.263","article-title":"Prognostic impact of cytogenetic abnormalities in patients with de novo acute non\u2010lymphocytic leukemia","volume":"73","author":"Schiffer CA","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.4.759.759"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90091-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.3.325"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830150311"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90087-O"},{"key":"e_1_2_1_15_2","first-page":"135","volume-title":"Human Cytogenetics","author":"Harrison CJ","year":"1986"},{"key":"e_1_2_1_16_2","unstructured":"Birth Defects 1985 21 ISCN: An International System for Human Cytogenetic Nomenclature"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"The French\u2010American British (FAB) Co\u2010operative Group: Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennet JM","year":"1982","journal-title":"Br J Haematol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1182\/blood.V67.6.1721.1721","article-title":"Refined chromosome analysis as an independent prognostic indicator in de\u2010novo myelodysplastic syndromes","volume":"6","author":"Yunis JJ","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880915)62:6<1129::AID-CNCR2820620616>3.0.CO;2-C"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07871.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1182\/blood.V81.4.1040.1040","article-title":"The 5q\u2010syndrome: A single institution study of 43 consecutive patients","volume":"81","author":"Mathews P","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830701)52:1<83::AID-CNCR2820520117>3.0.CO;2-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood.V67.6.1765.1765","article-title":"Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes","volume":"67","author":"Jacobs RH","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(92)90105-G"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460415"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861215)58:12<2571::AID-CNCR2820581202>3.0.CO;2-O"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V66.1.189.189","article-title":"Clinical characteristics and prognosis of 50 patients with a myeloproliferative syndrome and deletion of part of the long arm of chromosome 5","volume":"66","author":"Dewald GW","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_29_2","first-page":"363","article-title":"Leukemic transformation in patients with 5q\u2010 and additional abnormalities","volume":"76","author":"Larripa L","year":"1991","journal-title":"Haematologica"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb00777.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1988.tb00223.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1986.tb00640.x"},{"key":"e_1_2_1_33_2","first-page":"566","article-title":"Clinical and prognostic implications of chromosome 5q deletions: 96 high resolution studied patients","volume":"5","author":"Pedersen B","year":"1991","journal-title":"Leukemia"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1182\/blood.V70.6.1705.1705","article-title":"The 5q\u2010abnormality","volume":"70","author":"Nimer SD","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood.V71.2.403.403","article-title":"Cytogenetic studies in patients with secondary leukemia\/dysmyelopoietic syndrome after different treatment modalities","volume":"71","author":"Whang\u2010Peng J","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1182\/blood.V76.6.1083.1083","article-title":"Chromosomal aberrations and prognostic factors in therapy related myelodysplasia and acute non\u2010lymphocytic leukemia","volume":"76","author":"Pedersen\u2010Bjergaard J","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900050203"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830490304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830490304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:59:18Z","timestamp":1698274758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830490304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/ajh.2830490304"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830490304","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}