{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:10:18Z","timestamp":1698307818864},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Persons with hemophilia or other HIV\u20101 risk factors may be more likely to have idiopathic CD4+ T\u2010lymphocytopenia (ICL). We determined the frequency of ICL in prospectively followed cohorts of HIV\u20101 seronegative hemophilic men and seronegative female sex partners of HIV\u20101 infected hemophilic men, and examined factors potentially associated with ICL. Seven of 304 (2.3%) seronegative hemophilic men and one of 160 (0.6%) female partners met the ICL definition, but the condition resolved for two of the men and for the sole female partner. All five men with persistent ICL had lymphocytopenia (&lt;1,200 total lymphocytes\/\u00fcl) and &lt;300 total CD4+ lymphocytes\/\u00fc only one had a low CD4+ percent\u2010 age. On the most recent measurement, 14.5% of the 304 seronegative hemophilic men had lymphoctopenia. Compared with matched hemophilic controls, men with persistent ICL more often had a history of liver disease (3\/5 cases, 0\/21 controls, <jats:italic>P<\/jats:italic> = 0.007) or splenomegaly (3\/5 cases, 4\/21 controls; <jats:italic>P<\/jats:italic> = 0.04), but not severe hemophilia, greater clotting factor concentrate exposure, high alanine aminotransferase levels, hepatitis B virus antigenemia, or detectable hepatitis C virus RNA in plasma. All five cases and 20\/21 controls had antibodies to hepatitis C virus present in their serum. In this cohort of hemophilic men, ICL was related to lymphocytopenia associated with liver disease rather than selective loss of CD4+ lymphocytes.<\/jats:p>","DOI":"10.1002\/ajh.2830490305","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:53:07Z","timestamp":1172065987000},"page":"201-206","source":"Crossref","is-referenced-by-count":5,"title":["Idiopathic CD4+ T\u2010lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men"],"prefix":"10.1002","volume":"49","author":[{"given":"Thomas R.","family":"O'Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Diamondstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Fried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Aledort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Eichinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Elaine","family":"Eyster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret W.","family":"Hilgartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian M.","family":"Di Bisceglie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Goedert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280601"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1987.3.355"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910263211701"},{"key":"e_1_2_1_5_2","first-page":"69","article-title":"Use of whole blood methods in assessment of immune parameters in immunodeficiency states","volume":"5","author":"Fletcher MA","year":"1987","journal-title":"Diagn Clin Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860050406"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-9-700"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(92)90036-A"},{"key":"e_1_2_1_9_2","first-page":"1374","article-title":"CD4+ T\u2010lymphocyte counts among seronegative heterosexual partners of persons infected with human immunodeficiency virus type 1","volume":"6","author":"O'Brien TR","year":"1993","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280614"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34394196614.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1182\/blood.V66.6.1317.1317","article-title":"Long\u2010term follow\u2010up of hemophiliacs with lymphocytopenia or thrombocytopenia","volume":"66","author":"Eyster ME","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1182\/blood.V82.4.1351.1351","article-title":"Effect on lymphocyte subsets of clotting factor therapy in human immunodeficiency virus\u20101 negative congenital clotting disorders","volume":"82","author":"Hassett J","year":"1993","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830490305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830490305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:59:22Z","timestamp":1698274762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830490305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/ajh.2830490305"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830490305","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}