{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:04:47Z","timestamp":1776132287224,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":4028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four patients were diagnosed with reactive hemophagocytic syndrome (RHPS) during a 7 month period. Of these, three patients were diagnosed with acquired immunodeficiency syndrome complicated by disseminated <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection, incompletely treated <jats:italic>Pneumocystis carinii<\/jats:italic> pneumonia and disseminated histoplasmosis respectively. The fourth patient had non\u2010Hodgkin's lymphoma of the mature T\u2010cell phenotype. Fever, bicytopenia, or pancytopenia, elevated serum lactate dehydrogenase (LDH) level (&gt;1,000 IU\/L), and hemophagocytic histiocytosis in smears of bone marrow aspirate were present in all patients. Hyperferritinemia (&gt;10,000 ng\/ml) was present in all (range 34,976 to 425,984 ng\/mL) and showed a decrease in the two patients who responded to therapy. Hyperferritinemia (&gt;10,000 ng\/ml) and elevated serum LDH (&gt;1,000 IU\/L) are important clues to the diagnosis of RHPS in the febrile cytopenic patient with immunodeficiency. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830490314","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:53:07Z","timestamp":1172065987000},"page":"247-249","source":"Crossref","is-referenced-by-count":32,"title":["Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases"],"prefix":"10.1002","volume":"49","author":[{"given":"Prasad Rao","family":"Koduri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godofredo","family":"Carandang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Demarais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197909)44:3<993::AID-CNCR2820440329>3.0.CO;2-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028709065134"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-5-387"},{"key":"e_1_2_1_5_2","first-page":"291","article-title":"Inflammatory cytokines in virus\u2010associated hemophagocytic syndrome","volume":"15","author":"Ohga S","year":"1993","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_1_6_2","first-page":"63","article-title":"Hemophagocytic lymphohistiocytosis: A hemophagocytic syndrome","volume":"9","author":"Favara BE","year":"1992","journal-title":"Sem Diag Pathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1989.tb11068.x"},{"key":"e_1_2_1_8_2","first-page":"29","article-title":"Diagnostic guidelines for hemophagocytic lymphohistiocytosis","volume":"18","author":"Henter J\u2010I","year":"1991","journal-title":"Sem Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.5.683"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb01269.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"14572","DOI":"10.1016\/S0021-9258(18)77341-9","article-title":"Translational control during the acute phase response. Ferritin synthesis in response to interleukin\u20101","volume":"265","author":"Rogers JT","year":"1990","journal-title":"J Biol Chem"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830490314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830490314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:00:27Z","timestamp":1698274827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830490314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/ajh.2830490314"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830490314","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}