{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T20:26:05Z","timestamp":1746476765703},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":3997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymoma has been associated with a variety of autoimmune disorders. We report a case of agranulocytosis and anemia in a 68\u2010year\u2010old woman with a spindle cell thymoma. She was unresponsive to treatment with antibiotics, granulocyte\u2010colony stimulating factor (G\u2010CSF), prednisone, and high\u2010dose intravenous immunoglobulin. Serial bone marrow examinations on this therapy showed progression from a cellular marrow with mild my\u2010eloid and erythroid hyperplasia and lymphocytosis, to granulocyte aplasia and severe erythroid hypoplasia. Her serum contained granulocyte\u2010specific antibodies and inhibited the growth in culture of her own marrow cells and marrow cells from a normal donor. An IgG fraction from her serum also inhibited the growth of marrow cells.<\/jats:p><jats:p>Although the patient's spindle cell thymoma was surgically removed, she remained neutropenic. She was treated with six plasma exchanges followed by 1,000 milligrams of intravenous cyclophosphamide 2 days after the final plasma exchange and daily G\u2010CSF. Three weeks later her peripheral blood showed marked leukocytosis with pronounced neutrophilia and a left shift. Although her agranulocytosis resolved, she died of fungal sepsis.<\/jats:p><jats:p>This case demonstrates that aggressive plasma exchange and immunosuppressive therapy may benefit patients with agranulocytosis associated with thymoma. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.2830490412","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:52:46Z","timestamp":1172065966000},"page":"336-340","source":"Crossref","is-referenced-by-count":11,"title":["Immune mediated agranulocytosis and anemia associated with thymoma"],"prefix":"10.1002","volume":"49","author":[{"given":"Kathy","family":"Postiglione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrry P.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Stroncek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80690-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1542\/peds.79.5.728","article-title":"Natural history of primary autoimmune neutropenia in infancy","volume":"79","author":"Conway LT","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01698373"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07506.x"},{"key":"e_1_2_1_6_2","first-page":"201","article-title":"Granulocyte antibody detection to diagnose immune granulocytopenia and transfusion reactions due 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