{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:58:57Z","timestamp":1760266737914,"version":"3.33.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":3966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the expression of a monoclonal antibody (HML\u20101) defined antigen that appears on human intestinal T\u2010lymphocytes in HTLV\u2010I\u2010related disease. We studied 25 ATL, and 24 healthy HTLV\u2010I carriers. Patients with acute ATL showed a variety of the expression of the HML\u20101 antigen (range 0.4\u201374.8%). HML\u20101 expression on mononuclear cells (MNCs) in blood from patients with chronic ATL ranged from 1.7\u201343.6% (mean 13.5%). This level of expression was less than that of patients with acute ATL, but not significantly. In patients with smoldering ATL, the degree of patients with acute ATL, but not significantly. In patients with smoldering ATL, the degree of expression ranged from 1.6\u201313.3% (mean 8.0%). In contrast to patients wtih acute ATL, MNCs from patients with acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), and B\u2010cell type chronic lymphocytic leukemia (B\u2010CLL) did not express the HML\u20101 antigen, except for the 2 patients with ALL. Healthy HTLV\u2010I carriers and healthy controls also were negative for HML\u20101 reactivity. In acute ATL, patients with gastrointestinal tract infiltration tended to have high expression of the HML\u20101 epitope. After stimulation with phytohemagglutinin (PHA), healthy HTLV\u2010I carriers showed significantly increased expression of the HML\u20101 epitope (<jats:italic>P<\/jats:italic>&lt; 0.05).<\/jats:p><jats:p>Recently, the \u03b27 integrin family has been found to play a specific role in mucosal localization or adhesion, and HML\u20101 protein was found to match the deduced \u03b27 N\u2010terminal sequence. We propose that the cellular gene responsible for HML\u20101 epitope expression may, like IL\u20102, IL\u20102R, etc., be transactivated by infection with HTLV\u2010I, and that HML\u20101 antigen gene expression by HTLV\u2010I infection may lead to infiltration of ATL cells with highly expressed HML\u20101 epitope into the gut mucosa.<\/jats:p>","DOI":"10.1002\/ajh.2830500102","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T14:53:08Z","timestamp":1172069588000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Expression of the intestinal T\u2010lymphocyte\u2010associated\u2010molecule recognized by the HML\u20101 antibody on mononuclear cells from HTLV\u2010I\u2010infected 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