{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:21:02Z","timestamp":1779373262279,"version":"3.53.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":3905,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The thrombocytopenia in chronic liver disease (CLD) has been attributed mainly to hypersplenism, although other factors such as reduced mean life span with increased platelet turnover have also been demonstrated. Immunological abnormalities have been described in the pathogenesis and progression of CLD. In this sense, many studies have reported elevated levels of platelet associated IgG (PAIgG) in patients with CLD, and it has been suggested that PAIgG could represent true antiplatelet antibody. In this study we used a glycoprotein (GP)\u2010specific immunoassay (MACE) to determine whether PAIgG or circulating antiplatelet antibodies, reacted against the GPIIb\/IIIa or GPIb\/IX complexes, in patients with CLD. Thirty\u2010six patients with CLD of diverse etiology were studied (20 female, mean age 53 years, range 38\u201375 years). 23 out of 36 patients (64%) had anti\u2010GP antibodies in MACE. Particularly, 12 had anti\u2010GPIb, 4 anti\u2010GPIIb\/IIIa, and 7 had both types of autoantibodies. The existence of these anti\u2010GP antibodies was not related with the blood platelet count or etiology of CLD.<\/jats:p><jats:p>These data show that in patients with CLD of diverse origin, there is a high prevalence of autoantibodies reacting specifically with platelet membrane GP, which constitutes the first evidence of the specific nature of platelet\u2010bound IgG in CLD. These findings suggest that in patients with CLD, an immune mechanism may participate in inducing or aggravating the thrombocytopenia.<\/jats:p>","DOI":"10.1002\/ajh.2830500305","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T14:38:18Z","timestamp":1172068698000},"page":"173-178","source":"Crossref","is-referenced-by-count":56,"title":["Platelet autoantibodies in patients with chronic liver disease"],"prefix":"10.1002","volume":"50","author":[{"given":"Jaime","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Accatino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Alfaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Brahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mezzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(87)90195-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6742.12"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80501-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105380"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.4.367"},{"key":"e_1_2_1_7_2","first-page":"217","article-title":"Kinetics and functional studies on platelets, fibrinogen and plasminogen in patients with hepatic cirrhosis","volume":"99","author":"Stein SF","year":"1982","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.1.49"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168872"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.1.8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-55-4-598"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.00181.x"},{"key":"e_1_2_1_13_2","first-page":"638","volume-title":"Diseases of the Liver","author":"Thomas HC","year":"1993"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000199084"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1981.tb01423.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02721.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207147"},{"key":"e_1_2_1_18_2","first-page":"655","article-title":"Association of increased immune complexes, platelet IgG and serum IgG in chronic active hepatitis","volume":"54","author":"Pfueller SL","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915043"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.1.362.362"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1991.tb00261.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb05942.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.4.1050.1050"},{"key":"e_1_2_1_24_2","first-page":"97","volume-title":"Progress in Hemostasis and Thrombosis","author":"George JN","year":"1991"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb01171.x"},{"key":"e_1_2_1_26_2","first-page":"26","article-title":"Serological, biochemical, and molecular aspects of platelet autoantigens","volume":"29","author":"Kiefel V","year":"1992","journal-title":"Semin Hematol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.4.1024.1024"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113250"},{"key":"e_1_2_1_29_2","first-page":"214","volume-title":"Immune Cytopenias. 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