{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:59:30Z","timestamp":1771016370643,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,10]],"date-time":"2002-04-10T00:00:00Z","timestamp":1018396800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe an unusual case of hepatosplenic T\u2010cell lymphoma in a 61\u2010year\u2010old man who presented with fever, hepatosplenomegaly, anemia, and thrombocytopenia. A spleen biopsy was consistent with T\u2010cell lymphoma. Cytogenetic studies did not reveal chromosome abnormalities. Using the polymerase chain reaction approach, clonality of the T\u2010cell receptor \u03b3\u2010chain gene rearrangement could be demonstrated, while Southern blot analysis disclosed only a germline configuration of the T\u2010cell receptor \u03b2 chain genes. Of interest, an immune\u2010mediated mechanism was demonstrated and was most likely responsible for erythrocyte and platelet destruction; this is, therefore, the first report of \u03b3 T\u2010cell lymphoma in association with Evans' syndrome. Initial steroid treatment was efficacious in limiting autoimmunity but constitutional symptoms did not subside. Chemotherapy (MACOP\u2010B) was successful in obtaining complete clinical remission. Finally, thrombocytopenia in \u03b3\u03b4 T\u2010cell lymphoma patients should be routinely evaluated for platelet autoantibodies. Am. J. Hematol. 69:272\u2013276, 2002.\u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.5555","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:21:03Z","timestamp":1030317663000},"page":"272-276","source":"Crossref","is-referenced-by-count":18,"title":["Hepatosplenic \u03b3\u03b4 T\u2010cell lymphoma presenting with immune\u2010mediated thrombocytopenia and hemolytic anemia (Evans' syndrome)"],"prefix":"10.1002","volume":"69","author":[{"given":"G.","family":"Motta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vianello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Menin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Nicolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Agata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Altavilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pietrogrande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Girolami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V75.11.2213.2213","article-title":"Hepatosplenic T\u2010cell lymphoma: sinusal\/ sinusoidal localization of malignant cells expressing the T\u2010cell receptor \u03b3\u03b4","volume":"75","author":"Farcet JP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199506000-00013"},{"key":"e_1_2_1_5_2","first-page":"122","article-title":"Identification of anti\u2010platelet autoantibodies by Western blot in 45 patients with idiopathic thrombocytopenic purpura (ITP)","volume":"77","author":"Fabris F","year":"1992","journal-title":"Haematologica"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_7_2","first-page":"101","article-title":"Epitope retrieval (unmasking) in immunohistochemistry","volume":"8","author":"Battifora H","year":"1995","journal-title":"Adv Pathol Lab Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199506000-00006"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060510"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00893.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199901)60:1<61::AID-AJH10>3.0.CO;2-L"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1951.03810010058005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00016"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80193-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002810000048"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01576-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(99)00066-8"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.5555","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.5555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:24:07Z","timestamp":1700306647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.5555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1002\/ajh.5555"],"URL":"https:\/\/doi.org\/10.1002\/ajh.5555","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}