{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:07:11Z","timestamp":1791338831381,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Prognostication in acute myeloid leukemia (AML) relies on clinical, molecular, and cytogenetic factors. In this retrospective study, we examined the impact of different levels of cytogenetic response on overall survival (OS) and event\u2010free survival (EFS) in AML. Among 973 adult AML patients treated at Cleveland Clinic (5\/2017\u20139\/2023), 563 patients had baseline cytogenetic data and post\u2010treatment response assessment available. Based on baseline and response cytogenetic status, patients were categorized into: normal to normal (NL\u2010Cy to NL\u2010Cy, <jats:italic>n<\/jats:italic>\u2009=\u2009221, 39%), normal or abnormal to gain (NL\/Abnl\u2010Cy to Gain\u2010Cy, <jats:italic>n<\/jats:italic>\u2009=\u200946, 8.2%), abnormal to persistent (Abnl\u2010Cy to Persistent\u2010Cy, <jats:italic>n<\/jats:italic>\u2009=\u200981, 14%), abnormal to partial response (Abnl\u2010Cy to Partial\u2010Cy, <jats:italic>n<\/jats:italic>\u2009=\u200920, 3.6%), and abnormal to complete response (Abnl\u2010Cy to NL\u2010Cy, <jats:italic>n<\/jats:italic>\u2009=\u2009195, 35%). Landmark analysis was used to account for post\u2010treatment assessments. The cohort had a median age of 62\u2009years (interquartile range: 52\u201369), 256 females (45%), 90% were White, and median follow\u2010up of 45.8\u2009months (range: 0.73\u2013191.3). The median OS and hazard ratios (HRs) from multivariable regression analysis were as follows: NL\u2010Cy to NL\u2010Cy: 37\u2009months (95% CI: 27\u201391), HR\u2009=\u2009reference; NL\/Abnl\u2010Cy to Gain\u2010Cy: 14\u2009months (95% CI: 8.6\u201330), HR\u2009=\u20091.5 (95% CI: 0.99\u20132.39); Abnl\u2010Cy to Persistent\u2010Cy: 13\u2009months (95% CI: 12\u201318), HR\u2009=\u20091.61 (95% CI: 1.13\u20132.31); Abnl\u2010Cy to Partial\u2010Cy: 25\u2009months (95% CI: 14\u2010NC), HR\u2009=\u20090.76 (95% CI: 0.39\u20131.49); and Abnl\u2010Cy to NL\u2010Cy: 27\u2009months (95% CI: 19\u2013101), HR\u2009=\u20091.25 (95% CI: 0.93\u20131.68) (<jats:italic>p<\/jats:italic>\u2009=\u20090.038). Achieving cytogenetic remission, complete or partial, was associated with better survival outcomes. These findings highlight the importance of monitoring cytogenetic responses to inform treatment decisions and support integrating cytogenetic response into risk\u2010adapted, personalized AML management strategies.<\/jats:p>","DOI":"10.1002\/ajh.70000","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:48:21Z","timestamp":1752230901000},"page":"1577-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Cytogenetic Response to Therapy on Long\u2010Term Survival in Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0428-3505","authenticated-orcid":false,"given":"John","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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