{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:00:13Z","timestamp":1792047613445,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170205"],"award-info":[{"award-number":["82170205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Donor preference for acute myeloid leukemia (AML) patients transplanted in second complete remission (CR2) remains unclear, and hematopoietic cell transplantation (HCT) with post\u2010transplant cyclophosphamide (PTCy) from a haploidentical donor (HAPLO) merits attention. Data of 3878 adult AML patients receiving a first allo\u2010HCT in CR2 from the European Society of Blood and Marrow Transplantation registry between 2010 and 2022 were analyzed. Univariate analyses and Cox regression models were used. Results of HCTs from 803 HAPLO PTCy, 1271 matched sibling donor (MSD), and 1804 matched unrelated donor (MUD) were analyzed. A higher proportion (80.7%) of patients with European LeukemiaNet (ELN2022) intermediate\u2212\/adverse\u2010risk cytogenetics received an allo\u2010HCT from HAPLO PTCy than from either MUD (79.6%) or MSD (70.2%). On multivariate analysis, HAPLO PTCy grafts (hazard ratio [HR]\u2009=\u20090.65, 95% confidence interval [CI] 0.51\u20130.82;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were associated with a lower relapse incidence (RI) compared with MSD HCTs, although non\u2010relapse mortality was higher (HR\u2009=\u20091.77, 95% CI 1.34\u20132.34;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No difference was observed with respect to leukemia\u2010free survival and graft\u2010versus\u2010host disease (GVHD)\u2010free, relapse\u2010free survival (GRFS) for HAPLO PTCy compared to MSD grafts. Notably, HAPLO PTCy HCT was associated with significantly lower RI (HR\u2009=\u20090.64, 95% CI 0.48\u20130.82;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), chronic GVHD (cGVHD) (HR\u2009=\u20090.64, 95% CI 0.51\u20130.81;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and extensive cGVHD (HR\u2009=\u20090.47, 95% CI 0.34\u20130.66;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) incidences compared to MUD HCTs. Collectively, HAPLO PTCy HCT was associated with superior GRFS (HR\u2009=\u20090.81, 95% CI 0.68\u20130.95;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013) than MUD HCT. For AML patients in CR2, HAPLO PTCy HCT is associated with lower RI and cGVHD, leading to superior GRFS compared with MUD HCTs.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70008","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T11:38:56Z","timestamp":1752320336000},"page":"1760-1771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Superior\n                    <scp>GVHD<\/scp>\n                    \u2010Free, Relapse\u2010Free Survival for Haploidentical Transplant With\n                    <scp>PTCy<\/scp>\n                    Than Matched Unrelated Donor for\n                    <scp>AML<\/scp>\n                    Patients Transplanted in Second Complete Remission: A Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-4959","authenticated-orcid":false,"given":"Yishan","family":"Ye","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris Office, H\u00f4pital Saint Antoine 184  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yakoub\u2010Agha","sequence":"additional","affiliation":[{"name":"CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Saint\u2010Louis Hospital, BMT Unit  Paris 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