{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:51:12Z","timestamp":1778939472435,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to distinguish between essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre\u2010PMF) using routine blood tests, with a focus on white blood cell (WBC) and platelet (PLT) levels. We evaluated the predicted probability of a pre\u2010PMF diagnosis based on the interaction between WBC and PLT levels using data from a logistic regression model involving 891 patients with ET and 180 patients with pre\u2010PMF. Patients were divided into four groups based on whether their WBC and PLT values were below or above the respective thresholds of 8.85\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L and 793\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L. The results showed that patients with low levels of both WBCs and PLTs had the lowest predicted probability of pre\u2010PMF (6%), indicating a profile more typical of ET. When either WBC or PLT levels were elevated, the probability increased to approximately 18%\u201319%, indicating a potential shift toward pre\u2010PMF features. Notably, patients with elevated levels of both WBCs and PLTs had the highest probability of a pre\u2010PMF diagnosis (26%), which was more than four times higher than that of the low\u2013low group. The association between combined WBC\/PLT levels and a pre\u2010PMF diagnosis remained significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), even when adjusting for serum lactate dehydrogenase (LDH) and splenomegaly. These findings suggest that elevated WBC and PLT levels together can serve as a practical and accessible diagnostic tool for supporting the differential diagnosis of ET or pre\u2010PMF in cases of uncertainty, and for deferring bone marrow biopsy in cases of early disease presenting with isolated thrombocytosis.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70017","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T11:33:24Z","timestamp":1753529604000},"page":"1772-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Clinically Applicable Model Using Blood Counts to Support the Diagnosis of Prefibrotic Myelofibrosis Versus Essential Thrombocythemia"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-6327","authenticated-orcid":false,"given":"Tiziano","family":"Barbui","sequence":"first","affiliation":[{"name":"FROM Research Foundation, Papa Giovanni XXIII Hospital  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Thiele","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Ghirardi","sequence":"additional","affiliation":[{"name":"FROM Research Foundation, Papa Giovanni XXIII Hospital  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Michael","family":"Kvasnicka","sequence":"additional","affiliation":[{"name":"University Clinic Wuppertal University of Witten\/Herdecke  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Gianelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and S.C. Anatomia Patologica, ASST \u2010Santi Paolo e Carlo University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-7629","authenticated-orcid":false,"given":"Heinz","family":"Gisslinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Hematology and Blood Coagulation Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-0730","authenticated-orcid":false,"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"CRIMM\u2010Centro Ricerca e Innovazione Delle Malattie Mieloproliferative, Azienda Ospedaliera\u2010Universitaria Careggi, Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1660-7013","authenticated-orcid":false,"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Tech University Health Sciences Center  El Paso Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-3821","authenticated-orcid":false,"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"WHO Classification of Tumours: Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe E. S.","year":"2001"},{"key":"e_1_2_9_3_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S. H.","year":"2008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.5298"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-293761"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.196"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-777805"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1816082"},{"key":"e_1_2_9_9_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S. H.","year":"2017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27216"},{"key":"e_1_2_9_11_1","volume-title":"The International Consensus Classification of Myeloid and Lymphoid Neoplasms","author":"Arber D. 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