{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:29:21Z","timestamp":1790980161254,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clonal hematopoiesis of indeterminate potential (CHIP) might impair prognosis of several cancer types. Since previous studies predominantly focused on CHIP after cancer diagnosis, little is known about whether CHIP prior to cancer diagnosis predicts outcome. We performed a prospective cohort study, including 63\u2009486 patients with cancer during 2006 to 2022 in the UK Biobank, to evaluate the association between pre\u2010diagnostic CHIP and survival of cancer patients. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox regression models. We identified 2860 patients with cancer and pre\u2010diagnostic CHIP, and 60\u2009626 cancer patients without CHIP. During a median follow\u2010up of 4.2\u2009years, 1162 patients died in the CHIP group (921 cancer\u2010specific deaths), and 17\u2009825 in the reference group (14\u2009785 cancer\u2010specific deaths). Cancer patients with pre\u2010diagnostic CHIP exhibited a higher rate of overall death (HR 1.18, 95% CI: 1.11\u20131.25) and cancer\u2010specific death (HR 1.17, 95% CI: 1.09\u20131.25) compared with the reference group. A significant association of both overall death and cancer\u2010specific death was observed for myeloproliferative neoplasms, multiple myeloma, breast cancer, non\u2010Hodgkin lymphoma, and acute myeloid leukemia\/myelodysplastic syndromes. The increased rate of both overall death and cancer\u2010specific death was noted for CHIP with\n                    <jats:italic>TET2<\/jats:italic>\n                    ,\n                    <jats:italic>SRSF2<\/jats:italic>\n                    , or\n                    <jats:italic>JAK2<\/jats:italic>\n                    mutation. These findings suggested extended clinical awareness in cancer patients with pre\u2010diagnostic CHIP.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70028","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:27:32Z","timestamp":1754908052000},"page":"1993-2003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Pre\u2010Diagnostic Clonal Hematopoiesis of Indeterminate Potential With Prognosis Among Patients With Cancer"],"prefix":"10.1002","volume":"100","author":[{"given":"Xinyuan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Olov","family":"Adami","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Institute of Health and Society University of Oslo  Oslo Norway"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-0349","authenticated-orcid":false,"given":"Tove","family":"W\u00e4sterlid","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, and Department of Hematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Clinical Medical Research Center of Hematology Diseases of Guangdong Province  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Feychting","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm 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