{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:21:47Z","timestamp":1791235307985,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Only few data are available regarding the efficacy and safety of thrombopoietin receptor agonists (TPO\u2010RAs) for treating systemic lupus erythematosus (SLE) and\/or antiphospholipid syndrome (APS)\u2010associated immune thrombocytopenia (ITP). We retrospectively assessed the efficacy and safety of TPO\u2010RAs in 80 adults with ITP in three subgroups: (1) 37 patients with definite or incomplete SLE and no antiphospholipid antibodies (APAs), (2) 27 patients with definite or incomplete SLE associated with APAs and no history of arterial or venous thrombotic events (TEs) and (3) 16 patients with APS. In total, 39 (48.8%) patients received eltrombopag, 14 (17.5%) romiplostim and 27 (33.8%) both TPO\u2010RAs sequentially. The overall response of ITP was 78.8%. In total, 17 (21.3%) patients had 21 TEs (7 venous and 14 arterials, including 3 catastrophic APS); 3 were fatal. The rate of TEs was 8.1% in the SLE or lupus without APAs group, 22.2% in the SLE or lupus with APAs group and 50% in the APS group. In 12 patients, TPO\u2010RAs were continued after TE onset, combined with an anticoagulant (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) and\/or an antiplatelet agent (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). Only one TE relapse occurred in the nine patients with TPO\u2010RAs maintained and combined with an anticoagulant after TE. TPO\u2010RAs may be effective safe in ITP associated with SLE and no APAs. Their use should be carefully considered in the presence of thrombotic risk factors and\/or APA positivity and should be avoided in patients with definite APS. When a TE occurs, risk of relapse is low with maintenance of the TPO\u2010RA combined with anticoagulation.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70052","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:16:32Z","timestamp":1759814192000},"page":"1972-1982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Thrombotic Risk of Thrombopoietin Receptor Agonists for Immune Thrombocytopenia Secondary to Systemic Lupus and Antiphospholipid Syndrome: French Experience With 80 Patients"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-0575","authenticated-orcid":false,"given":"Cindy","family":"Marques","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, French Referral Centre for Adult Immune Cytopenia Henri Mondor Hospital, AP\u2010HP, UPEC University  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Moulis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Roussotte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Universitaire Croix\u2010Rousse, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Bonnotte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire de Dijon  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Viallard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne et Maladies Infectieuses Centre Hospitalier Universitaire Haut L\u00e9v\u00eaque, Universit\u00e9 de Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Graveleau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-8432","authenticated-orcid":false,"given":"Herv\u00e9","family":"Lobbes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire de Clermont Ferrand  Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Costedoat\u2010Chalumeau","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladies Auto\u2010Immunes et Syst\u00e9miques Rares de L'\u00eele de France, Cochin Hospital Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Deroux","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Grenoble University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gobert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Saint\u2010Antoine  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Dossier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Bichat  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-0859","authenticated-orcid":false,"given":"Laurent","family":"Gilardin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Jean Verdier  Bondy 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