{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:33:03Z","timestamp":1790343183932,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502700"],"award-info":[{"award-number":["2022YFC2502700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200237"],"award-info":[{"award-number":["82200237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370215"],"award-info":[{"award-number":["82370215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Given the dismal prognosis for patients with\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated acute myeloid leukemia (AML), the optimal donor for those undergoing allogeneic hematopoietic cell transplantation (allo\u2010HCT) remains unclear. We retrospectively analyzed adult patients with\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated AML who underwent first allo\u2010HCT in CR1 between 2010 and 2021. Outcomes were compared among using a haploidentical donor (Haplo), a matched sibling donor (MSD), and a 10\/10 matched unrelated donor (MUD). The analysis comprised 451 patients, including 86 Haplo, 117 MSD, and 248 MUD. Patients in the three groups were transplanted during a similar period. Haplo, MSD, and MUD groups experienced similar incidences of Day 180 Grades II\u2013IV aGVHD (30.9% vs. 23.6% vs. 28.3%), Grades III\u2013IV aGVHD (13.6% vs. 10.1% vs. 9.1%), 2\u2010year cGVHD (28.9.% vs. 30.9% vs. 25.6%) and extensive cGVHD (10.9% vs. 16.1% vs. 13.3%). By multivariate analysis, the outcomes were similar in the three groups. The MSD group was associated with a similar 2\u2010year overall survival (OS: 33.9%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.799), leukemia\u2010free survival (LFS: 30.5%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.956), relapse incidence (RI: 54.2%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.497), non\u2010relapse mortality (NRM: 15.3%;\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.368), and GVHD\u2010free, relapse\u2010free survival (GRFS: 21.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.957) when compared with the Haplo group (2\u2010year OS: 46.7%, LFS: 37.4%, RI: 40.8%, NRM: 21.7%, GRFS: 25.7%). The MUD group also experienced a similar 2\u2010year OS (36.9%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.892), LFS (31%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.904), RI (50.8%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.521), NRM (18.2%;\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.368) and GRFS (21.9%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.383) when compared with the Haplo group. In conclusion, outcomes of patients with\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated AML undergoing allo\u2010HCT from a haploidentical donor were comparable to those from an MSD or 10\/10 MUD HCT.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70069","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:51:51Z","timestamp":1757494311000},"page":"2220-2229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Similar Outcome With Haploidentical, Matched Sibling, or Matched Unrelated Donor Hematopoietic Cell Transplantation for Adult Patients With Adverse\u2010Risk\n                    <i>TP53<\/i>\n                    \u2010Mutated Acute Myeloid Leukemia in First Remission: A Comparative Study From the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2462-047X","authenticated-orcid":false,"given":"Yuhua","family":"Ru","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology  Suzhou China"},{"name":"Department of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-5039","authenticated-orcid":false,"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology  Suzhou China"},{"name":"Department of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allain\u2010Thibeault","family":"Ferhat","sequence":"additional","affiliation":[{"name":"EBMT Paris Office H\u00f4pital Saint Antoine, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Labussi\u00e8re\u2010Wallet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lyon Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Gedde\u2010Dahl","sequence":"additional","affiliation":[{"name":"Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"University Hospital Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"H\u00f4spital Saint\u2010Louis  Paris 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