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Currently, however, there is an entrenched prescription\u00a0of\u00a0D\u2010dimer testing to screen otherwise healthy subjects that may induce prescribing physicians to start time\u2010consuming diagnostic\u00a0procedures that may generate patient anxiety\/distress and often fail to reach meaningful conclusions\u00a0for patients' management. To make things worse, the incidental finding of unexplained elevated D\u2010dimer is often, and inadvertently, taken\u00a0as an index of venous thromboembolism (VTE) that may induce unnecessary initiation of thromboprophylaxis. Finally,\u00a0population studies showed that elevated D\u2010dimer is variably associated with arterial thrombosis. However, the\u00a0above\u00a0studies do not allow establishing a direct causal relationship between elevated D\u2010dimer and disease, which makes D\u2010dimer measurement hardly applicable in individual patients. With this as background, the Italian Society on Thrombosis and Hemostasis\u00a0appointed a panel to prepare a guidance on the use of D\u2010dimer based on the literature and expert opinion. The main conclusions\u00a0of the panel can be summarized as follows: (i) D\u2010dimer can be reliably used in combination with pre\u2010test clinical\u00a0probability to exclude VTE in symptomatic outpatients. (ii) It may help establish the optimal duration of secondary VTE prevention\u00a0with vitamin K antagonists, although the panel felt that this area needs further investigation when\u00a0dealing\u00a0with direct oral anticoagulants. (iv) The use of D\u2010dimer in combination with the pre\u2010test probability score can be used to safely rule out acute aortic syndromes in the emergency setting without further imaging tests.<\/jats:p>","DOI":"10.1002\/ajh.70079","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:45:50Z","timestamp":1759135550000},"page":"97-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Facts and Misfacts on\n                    <scp>D<\/scp>\n                    \u2010Dimer Testing. 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