{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:04:10Z","timestamp":1775217850252,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Light chain multiple myeloma (LCMM) is a subtype of multiple myeloma (MM) characterized by the exclusive production of immunoglobulin light chains and accounts for 15%\u201320% of newly diagnosed MM. A comprehensive comparison of LCMM with MM producing intact immunoglobulin (non\u2010LCMM) remains limited. In this retrospective study, we described distinct clinical and cytogenetic features and assessed long\u2010term outcomes in 852 LCMM patients diagnosed between 01\/01\/2004 and 12\/31\/2022, compared with non\u2010LCMM controls matched for age, sex, and year of diagnosis. On univariable analysis, LCMM patients were more likely to present with elevated creatinine (&gt;\u20092\u2009mg\/dL), beta\u20102\u2010microglobulin \u2265\u20095.5\u2009mg\/L, elevated LDH, hypercalcemia, t(11;14), del(13q), and t(6;14). Conversely, IMS\u2010IMWG high\u2010risk disease, hyperdiploidy, t(4;14), and serum albumin &lt;\u20093.5\u2009g\/dL were less common. On multivariable analysis, elevated creatinine (OR: 5.1, 95% CI: 1.2\u201327,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), t(11;14) (OR: 2.6, 95% CI: 1.3\u20135.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), and del(13q) (OR: 4.1, 95% CI: 2.1\u20138.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were independently associated with LCMM, while IMS\u2010IMWG high\u2010risk disease (OR: 0.3, 95% CI: 0.1\u20130.8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and hyperdiploidy (OR: 0.3, 95% CI: 0.1\u20130.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) were less frequent. Despite these differences, progression\u2010free survival with frontline treatment (HR: 0.97, 95% CI: 0.84\u20131.11,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.63) and overall survival (HR: 0.99, 95% CI: 0.87\u20131.13,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.94) were similar between LCMM and non\u2010LCMM patients. This study highlights the distinct clinical and cytogenetic features of LCMM, marked by higher rates of renal failure, t(11;14), and del(13q), lower prevalence of IMS\u2010IMWG high\u2010risk disease, and comparable survival outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70099","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:05:51Z","timestamp":1759565151000},"page":"2286-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics, Treatment Responses and Outcomes of Light Chain Multiple Myeloma"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-1954","authenticated-orcid":false,"given":"Abiola","family":"Bolarinwa","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-8453","authenticated-orcid":false,"given":"Saurabh","family":"Zanwar","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-1589","authenticated-orcid":false,"given":"Nadine","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis K.","family":"Buadi","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne R.","family":"Hayman","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota 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Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-969X","authenticated-orcid":false,"given":"Wilson","family":"Gonsalves","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-9434","authenticated-orcid":false,"given":"Taxiarchis","family":"Kourelis","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-3004","authenticated-orcid":false,"given":"David","family":"Dingli","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota 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