{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:17:58Z","timestamp":1784546278137,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Survival outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) have improved with modern frontline therapies and minimal residual disease (MRD)\u2010guided strategies. As a result, allogeneic hematopoietic cell transplantation (HCT) is increasingly deferred in first remission (CR1) and used in the relapsed setting. However, data on HCT outcomes in second remission (CR2) remain limited in AYAs. We conducted a dual\u2010center retrospective study of AYA patients aged 15\u201340\u2009years who underwent HCT in CR2 between 2010 and 2022. Among 164 patients, the median age was 25\u2009years; 66% were male and 80% had B\u2010ALL. Frontline therapies included pediatric\u2010inspired (54%) and hyperCVAD\u2010based (33%) regimens. Most received myeloablative conditioning (74%), and 67% were MRD\u2010negative at HCT. At a median follow\u2010up of 36\u2009months, 3\u2010year overall survival (OS) and progression\u2010free survival (PFS) were 53% and 46%. The 3\u2010year cumulative incidences of relapse and non\u2010relapse mortality were 36% and 18%, respectively. The 6\u2010month incidence of grade 2\u20134 acute graft\u2010versus\u2010host disease (GVHD) was 36%, and grade 3\u20134 was 14%. Chronic GVHD occurred in 27% at 3\u2009years, with 37% moderate and 25% severe. On multivariable analysis, a HCT\u2010specific comorbidity index &gt;\u20093 was independently associated with inferior OS, PFS, and higher non\u2010relapse mortality. MRD positivity predicted worse PFS and higher relapse risk but not OS. These findings support HCT in CR2 as a curative option for AYA patients with ALL. Outcomes are influenced by MRD status and comorbidities, underscoring the need for risk\u2010adapted transplant strategies.<\/jats:p>","DOI":"10.1002\/ajh.70101","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:38:03Z","timestamp":1759793883000},"page":"16-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allogeneic Hematopoietic Stem Cell Transplantation in\u00a0Adolescents and Young Adults With Acute Lymphoblastic Leukemia\u2014A Retrospective, Dual\u2010Center Study"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-0059","authenticated-orcid":false,"given":"Oren","family":"Pasvolsky","sequence":"first","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas 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University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Rondon","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Patient Care The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8199-9404","authenticated-orcid":false,"given":"Dristhi","family":"Ragoonanan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Patient Care The University of Texas M.D. Anderson Cancer Center  Houston Texas 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