{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:24:12Z","timestamp":1790288652908,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute renal failure due to cast nephropathy (CAN) is a severe complication of multiple myeloma (MM). Here, we aimed to identify parameters associated with renal outcomes and survival in newly diagnosed MM patients with CAN\u2010related acute renal failure and to validate the IMWG criteria for renal response. CAN diagnosis was based on biopsy or clinical assessment. Of 787 registered patients, 354 met the inclusion criteria, requiring at least two therapy cycles with documented chemotherapy response, renal response, and eGFR. Baseline free light chain (FLC) levels (median 6825.65\u2009mg\/L) decreased below 500\u2009mg\/L in 67.8% of patients. According to IMWG classification, renal complete response, partial response, and minimal response were achieved in 33.9%, 19.5%, and 28.0% of patients, respectively. The best eGFR values &gt;\u200960\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    were observed in 33.9% of patients, while 33.3%, 22.3%, and 10.5% had best eGFR values of 30\u201359, 15\u201329, and\u2009&lt;\u200915\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    , respectively. Renal response correlated with baseline FLC levels, IgG kappa, eGFR, and ECOG status in multivariate analysis, as well as with myeloma response and FLC reduction in univariate analysis. Median overall survival was 77.6\u2009months. Survival correlated with age, myeloma response, ECOG status, FLC kappa type, baseline eGFR, standard\u2010risk cytogenetics, and calcium levels, among other factors. A comparison of IMWG renal response criteria with classification based solely on best eGFR showed similar utility. Of 136 patients requiring dialysis, 80 (58.8%) were able to discontinue dialysis during therapy. Bortezomib containing myeloma therapy, along with significant FLC reduction, was associated with favorable outcome.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70104","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:53:26Z","timestamp":1761310406000},"page":"56-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Parameters Associated With Renal Recovery and Survival in Myeloma Patients With Acute Renal Failure to Cast Nephropathy"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-8726","authenticated-orcid":false,"given":"Heinz","family":"Ludwig","sequence":"first","affiliation":[{"name":"Wilhelminen Cancer Research Institute, c\/o Department of Medicine I Clinic Ottakring  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens Greece"},{"name":"Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bernhard","sequence":"additional","affiliation":[{"name":"Wilhelminen Cancer Research Institute, c\/o Department of Medicine I Clinic Ottakring  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-0351","authenticated-orcid":false,"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Beksac","sequence":"additional","affiliation":[{"name":"Department of Hematology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guldane","family":"Cengiz\u2010Seval","sequence":"additional","affiliation":[{"name":"Department of Hematology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-1411","authenticated-orcid":false,"given":"Nelson","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-991X","authenticated-orcid":false,"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinic San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-3083","authenticated-orcid":false,"given":"Silvia","family":"Mangiacavalli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinic San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bridoux","sequence":"additional","affiliation":[{"name":"Department of Nephrology &amp; Renal Transplantation Universit\u00e9 de Poitiers, Centre Hospitalier Universitaire  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-0211","authenticated-orcid":false,"given":"Hermine","family":"Agis","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Division Hematology and Hemostaseology Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Chaidos","sequence":"additional","affiliation":[{"name":"Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation Imperial College London and Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gay","sequence":"additional","affiliation":[{"name":"Myeloma Unit, Division of Hematology University of Torino, Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Roccatello","sequence":"additional","affiliation":[{"name":"ASL Citt\u00e0 di Torino and Department of Clinical and Biological Sciences of the University of Turin San Giovanni Bosco Hub Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hilbe","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Center for Oncology and Hematology Clinic Ottakring  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Havasi","sequence":"additional","affiliation":[{"name":"Renal Section, Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Derudas","sequence":"additional","affiliation":[{"name":"Department of Hematology Businco Hospital  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-2523","authenticated-orcid":false,"given":"Nattawat","family":"Klomjit","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-0524","authenticated-orcid":false,"given":"Kenar D.","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Division of Kidney Diseases and Hypertension Northwell Health, Zucker School of Medicine at Hofstra\/Northwell  Great Neck New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"De La Rubia Comos","sequence":"additional","affiliation":[{"name":"University Hospital La Fe, Universidad Catolica \u201cSan Vicente Martir\u201d, Instituto de Investigation Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-5832","authenticated-orcid":false,"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz211"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0077-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.72"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080857"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.11.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119218"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.5.662"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00660.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.079236"},{"key":"e_1_2_9_11_1","first-page":"46","article-title":"Renal Disorders and Calcium Phosphorus Tubular Dysfunctions in Multiple Myeloma","volume":"37","author":"Goranov S.","year":"1995","journal-title":"Folia Medica (Plovdiv)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.168"},{"key":"e_1_2_9_13_1","first-page":"222","article-title":"Renal Histological Lesions and Clinical Syndromes in Multiple Myeloma. 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