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This makes this molecule an important target for the diagnosis and treatment of CD30\u2010expressing lymphomas. We describe the road to the discovery of the CD30 molecule and the way CD30 has contributed to more precise diagnosis and classification of lymphomas. Moreover, we address how anti\u2010CD30 immunotherapy was developed and the impact of the anti\u2010CD30\u2010auristatin conjugate and anti\u2010CD30 CAR\u2010T cells in treating CD30\u2010expressing lymphomas.<\/jats:p>","DOI":"10.1002\/ajh.70107","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:25:30Z","timestamp":1761135930000},"page":"110-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>CD30<\/scp>\n                    as a Target Molecule in the Diagnosis and Therapy of Lymphomas"],"prefix":"10.1002","volume":"101","author":[{"given":"Harald","family":"Stein","sequence":"first","affiliation":[{"name":"Past Berlin Reference Pathologist of the German Reference Center for Hematopathology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-5965","authenticated-orcid":false,"given":"Brunangelo","family":"Falini","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Center for Hemato\u2010Oncological Research (CREO), University of Perugia and Santa Maria Della Misericordia Hospital  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_17_2_1","volume-title":"Pathologie der Halslymphknoten. 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