{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:33Z","timestamp":1786976853606,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL\u2010153161"],"award-info":[{"award-number":["R01 HL\u2010153161"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24 HL\u2010177273"],"award-info":[{"award-number":["K24 HL\u2010177273"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic kidney disease (CKD) is common and a major contributor to increased morbidity and early mortality in people with sickle cell anemia (SCA). Urine albumin\u2010to\u2010creatinine ratio (uACR) is recommended to identify patients with SCA\u2010related CKD but its utility in predicting long\u2010term kidney dysfunction remains unclear in this patient population. In two independent, longitudinal cohorts of patients with hemoglobin SS or S\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia (USA:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009268, median follow\u2010up 6\u2009years; France:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009310, median follow\u2010up 8.2\u2009years) we investigated the utility of uACR, as well as other clinical and modifiable risk factors, for predicting a decline in kidney function as determined by the rate of estimated glomerular filtration rate (eGFR) decline. Using linear mixed\u2010effects models, a higher baseline uACR independently predicted a faster rate of eGFR decline as well as a more rapid annual eGFR decline, defined as \u2265\u20093\u2009mL\/min\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.009). Furthermore, baseline uACR of \u2265\u2009100\u2009mg\/g creatinine was independently associated with the rate of eGFR decline and rapid annual eGFR decline in both cohorts. Tobacco smoking was also associated with a faster rate of eGFR decline and was congruous between the two cohorts. In conclusion, we demonstrate that uACR is an important clinical tool that predicts a more rapid decline in kidney function and should be routinely monitored in people with SCA. Our data also support preventative care to reduce tobacco smoking for mitigating the risk of CKD progression in this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70155","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:36:29Z","timestamp":1764772589000},"page":"304-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia"],"prefix":"10.1002","volume":"101","author":[{"given":"Pablo","family":"Bartolucci","sequence":"first","affiliation":[{"name":"H\u00f4pital Henri Mondor Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP) Univ Paris Est\u2010Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9tienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Mondor Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP) Univ Paris Est\u2010Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Department, Henri Mondor University Hospital, APHP Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Univ Paris Est\u2010Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[{"name":"Red Cell Genetic Disease Unit, H\u00f4pital Henri\u2010Mondor, AP\u2010HP Universit\u00e9 Paris Est  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-3399","authenticated-orcid":false,"given":"Guillaume","family":"Lettre","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qu\u00e9bec Canada"},{"name":"Montreal Heart Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine","family":"Anthony","sequence":"additional","affiliation":[{"name":"Novartis Global Health  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufolake","family":"Egbujo","sequence":"additional","affiliation":[{"name":"Novartis Global Health  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-006X","authenticated-orcid":false,"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4219","authenticated-orcid":false,"given":"Maria Armila","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Medicine University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-7295","authenticated-orcid":false,"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Medicine University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-1385","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Medicine University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-4194","authenticated-orcid":false,"given":"Santosh L.","family":"Saraf","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; 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