{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:17:16Z","timestamp":1783606636331,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002957","name":"Technische Universit\u00e4t Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anthracyclines are an essential component of induction therapy for acute myeloid leukemia (AML), but their optimal dosing and the associated risk for cardiotoxicity remain under debate. The DaunoDouble trial compared daunorubicin at 60 (Dauno60) versus 90\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (Dauno90) in combination with cytarabine (100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    for 7\u2009days) in newly diagnosed AML patients aged 18\u201365\u2009years. Cardiac function was assessed by left ventricular ejection fraction (LVEF) and cardiac biomarkers (high\u2010sensitivity troponin T [hsTnT], NT\u2010proBNP) before treatment and on Day 15 in 317 randomized patients. Median LVEF declined significantly from 65% [IQR 60%\u201368.5%] to 61% [IQR 58%\u201367.8%] across all patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), without significant differences between treatment arms. NT\u2010proBNP levels measured after induction therapy correlated negatively with LVEF at the same time point (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u2009\u22120.24,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02), but did not change significantly during induction\u2014neither between Day 1 and 15 nor between treatment arms. HsTnT levels increased significantly from 5 [IQR 4\u20138] to 8\u2009ng\/L [IQR 6\u201314] across all patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), with higher post\u2010induction values in the Dauno90 group (9.5\u2009ng\/L [IQR 7\u201314]) compared to Dauno60 (7\u2009ng\/L [IQR 5\u201314];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). In exploratory subgroup analyses, post\u2010induction hsTnT levels were also significantly higher in patients with obesity and arterial hypertension. These findings provide evidence of a dose\u2010dependent cardiotoxic effect of daunorubicin, already apparent at standard induction doses, and underscore the importance of early cardiac monitoring. Long\u2010term follow\u2010up will be essential to determine the clinical significance of these early changes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT02140242\n                  <\/jats:p>","DOI":"10.1002\/ajh.70160","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:07:10Z","timestamp":1767683230000},"page":"512-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized Comparison of Cardiotoxicity With 60 Versus 90\u2009mg Daunorubicin in\n                    <scp>AML<\/scp>\n                    Induction Therapy"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4323-521X","authenticated-orcid":false,"given":"Stefan Markus","family":"Dendorfer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"},{"name":"Cognium GmbH  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schmidt\u2010Br\u00fccken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schliemann","sequence":"additional","affiliation":[{"name":"Department of Medicine A University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Henrik","family":"Mikesch","sequence":"additional","affiliation":[{"name":"Department of Medicine A University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nael","family":"Alakel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Herbst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Chemnitz Hospital  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"H\u00e4nel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Chemnitz Hospital  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-8940","authenticated-orcid":false,"given":"Maher","family":"Hanoun","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Hematology Robert\u2010Bosch\u2010Krankenhaus  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Weinbergerova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University Hospital Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sch\u00e4fer\u2010Eckart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Nuremberg Hospital North, Paracelsus Medical University  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology, Oncology and Immunology University Hospital Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Burchert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology, Oncology and Immunology University Hospital Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolana","family":"Mertov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation University Hospital Aachen &amp; CIO ABCD Aachen, RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Niemann","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Palliative Care Gemeinschaftsklinikum Mittelrhein  Koblenz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nov\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Haematology, 3rd Faculty of Medicine Charles University and University Hospital Kralovske Vinohrady  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W.","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University Hospital Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Scholl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hochhaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Westpfalzklinikum  Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Szotkowski","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Palack\u00fd University  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rank","sequence":"additional","affiliation":[{"name":"II. Medical Clinic University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schmid","sequence":"additional","affiliation":[{"name":"II. Medical Clinic University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Fransecky","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-8843","authenticated-orcid":false,"given":"Sabine","family":"Kayser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Hematology and Cellular Therapy University Hospital Leipzig  Leipzig Germany"},{"name":"NCT Trial Center, National Center for Tumor Diseases, German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schaich","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Palliative Care Rems\u2010Murr\u2010Klinikum  Winnenden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Fiebig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Haake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schetelig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Moritz","family":"Middeke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thiede","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"},{"name":"Agendix GmbH  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"M\u00fcller\u2010Tidow","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[{"name":"Department of Medicine A University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Ehninger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-9887","authenticated-orcid":false,"given":"Jiri","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University Hospital Brno  Brno Czech 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00235"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.654"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2005.02.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013777"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338335"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/hj.1998.v136.89908"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0398"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(68)90143-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181efbc4e"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"33","article-title":"High\u2010Sensitivity Troponin T Is Detectable in Most Patients With Clinically Stable Heart Failure","volume":"21","author":"Lyons K. S.","year":"2014","journal-title":"British Journal of Cardiology"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803547-4.00007-0"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2023.2269086"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020276"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:45:32Z","timestamp":1771235132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ajh.70160"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70160","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}